header image

[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

Inside
Weather


 
Calendar
Today in
S.C.V. History
March 29
1928 - Little dam victim, thought unidentified & buried in SCV, actually ID'd & buried in Chatsworth [story]
Newhall Cowboys


[SetPoint] – SetPoint Medical, a Valencia-based biomedical technology company developing neuromodulation therapies for inflammatory diseases, presented positive results from a first-in-human study using a neuromodulation device to treat rheumatoid arthritis (RA) Sunday at the American College of Rheumatology annual meeting in Washington, D.C.

“In contrast to immunosuppressive drugs, the neuromodulation therapy in this study used an implantable pulse generator to stimulate the vagus nerve, activating the body’s natural Inflammatory Reflex to produce a systemic anti-inflammatory effect,” said Dr. Kevin Tracey, President of Feinstein Institute for Medical Research, discoverer of the inflammatory reflex, and co-author of the ACR presentation. “The results of this study show promising clinical efficacy, and confirm a decade of foundational scientific research done by our laboratory and others.”

“This study validates neuromodulation as a breakthrough approach to treating RA and other autoimmune and inflammatory diseases,” said Anthony Arnold, chief executive officer of SetPoint Medical. “We look forward to developing safe and effective alternative therapies for a range of inflammatory diseases such as Crohn’s disease, ulcerative colitis, psoriasis, and for the inflammation that worsens diabetes and heart disease. This approach could offer patients 10 years of treatment for the cost of about 18 months of biologic therapy and would be an exciting new alternative for physicians to treat their patients.”

In this open label pilot study, eight patients with active rheumatoid arthritis despite treatment with the RA agent methotrexate, who would otherwise have been candidates for a TNF inhibitor, instead received the neuromodulation implant on the vagus nerve in their neck. The treatment was well tolerated, with one patient reporting hoarseness after implantation, a known side effect with this type of device. Improvement in RA was assessed at the six-week primary endpoint using standard measures of efficacy including the Disease Activity Score (DAS), and the American College of Rheumatology (ACR) 20 response rate.

At the primary end point, two of the eight patients in the study achieved DAS remission, and six of the eight had a positive ACR 20 response, results similar to those typically achieved in larger studies with drugs currently used to treat RA.

SetPoint is developing a novel platform to treat a variety of inflammation-mediated autoimmune diseases. The company is planning larger clinical studies in several diseases scheduled to begin in 2013.

 

About SetPoint Medical

SetPoint Medical is a privately held biomedical technology company dedicated to treating patients with debilitating inflammatory diseases using proprietary implantable neuromodulation devices.

SetPoint is developing safe and effective neuromodulation therapies for patients with inflammatory autoimmune diseases, such as Crohn’s Disease and rheumatoid arthritis. SetPoint’s novel platform consists of an implantable miniature neuromodulation device, wireless charger and iPad prescription pad application. The system uses vagus nerve stimulation to activate the body’s natural Inflammatory Reflex, which produces a potent systemic anti-inflammatory effect. The company has just completed a first-in-human open-label proof-of-concept trial in rheumatoid arthritis. The results confirm extensive preclinical studies, and show clinical efficacy comparable to leading immunosuppressive drugs. SetPoint’s approach is intended to offer patients and providers a better alternative approach for the treatment of RA and other chronic inflammatory diseases with less risk and cost than drug therapy. SetPoint is headquartered in Valencia, Ca., and investors in the company include Morgenthaler Ventures, Foundation Medicine and Topspin Partners. For more information, visit www.setpointmedical.com.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

No Comments

    Leave a Comment


    Latest Additions to SCVNews.com
    1928 - Little dam victim, thought unidentified & buried in SCV, actually ID'd & buried in Chatsworth [story]
    Newhall Cowboys
    Los Angeles County Public Works is updating the Los Angeles County Bicycle Master Plan.
    April 16:  County Bicycle Master Plan Virtual Community Meeting
    College of the Canyons mens golf got back on track during its return to conference play on Monday, carding a five-man score of 370 to top the eight-team field at Brookside Golf Course and maintain its unblemished conference mark.
    Cougars Win Again, Keep Conference Streak
    Los Angeles County Treasurer and Tax Collector, reminds property owners that the second installment of the 2023-24 Annual Secured Property Taxes becomes  delinquent if not received by 5 p.m. Pacific Time or United States Postal Service postmarked on or before Wednesday, April 10, 2024.
    County Treasurer Reminds Property Owners of April 10 Due Date
    Local nonprofit Fostering Youth Independence is seeking “Allies” to support Santa Clarita youth who are aging out of the L.A. County foster care system.
    April 16: FYI Seeks Volunteers To Pair With Local Foster Youth
    The Los Angeles County Department of Public Health today unveiled the latest L.A. County Health Survey, which gathers vital data on health behaviors, conditions, neighborhood settings, and the needs of L.A .County residents, informing future public health policies and programs.
    Public Health Unveils the 2023 L.A. County Health Survey Findings
    Due to the projected rain forecast, Eggstravaganza will now be held indoors at the Canyon Country Community Center beginning promptly at 10 a.m. on March 30.
    March 30: Eggstravaganza Now Being Held Indoors at Canyon Country Community Center
    To support the mental health of California's young people, the California Department of Public Health awarded $25 million to 28 tribal and community-based organizations across the state.
    California Announces $25 Million in Awards for Youth Mental Health
    The College of the Canyons Athletic Department will host a dedication ceremony to unveil the Michele Jenkins Softball Team Room in honor of the longtime board member and ardent softball program supporter’s nearly 40 years of service to the district.
    April 16: COC to Host Michele Jenkins Team Room Dedication Ceremony
    PFLAG Santa Clarita has announced the establishment of the Peggy and Jeff Stabile PFLAG SCV Scholarship. The scholarship will provide financial assistance to LGBTQIA+ students pursuing higher education and committed to advocating for LGBTQIA+ rights and promoting diversity and inclusion.
    PFLAG SCV Announces Stabile PFLAG Scholarship
    1934 - Bouquet Canyon Reservoir, replacement for ill-fated St. Francis Dam & reservoir, begins to fill with water [story]
    Bouquet Reservoir
    The California Department of Public Health launched the “Never a Bother” campaign, a youth suicide prevention public awareness and outreach campaign for youth, young adults, and their parents, caregivers, and allies.
    California Launches New Youth Suicide Prevention Campaign
    The Santa Clarita Master Chorale invites the community to "Let the Sunshine In," a delightful evening of food, wine and song at the annual Cabaret & Cabernet fundraising benefit.
    April 20: Santa Clarita Master Chorale’s Cabaret, Cabernet Fundraiser
    The Los Angeles County Department of Public Health cautions residents who are planning to visit the below Los Angeles County beaches to avoid swimming, surfing, and playing in ocean waters:
    March 27 Ocean Water Warning
    As an integral ingredient necessary to help the Santa Clarita Valley to flourish, feedback from the business community is the secret sauce for achieving great things.
    SCVEDC Asks For the Business Community’s Opinion on Santa Clarita
    Raise your heart rate while raising funds for the Santa Clarita Sister Cities Dollars-for-Desks campaign to provide school desks for students in Sariaya, Santa Clarita's Sister City in the Philippines.
    April 13: Sister Cities Zumba-thon Fundraiser
    Remo, Inc. is is the world's leading manufacturer and developer of synthetic drumheads and shells. They’ve been in business for 60 years
    SCVEDC Company Spotlight: Drumming Up Big Business with Remo, Inc.
    California State Assemblywoman Pilar Schiavo (D-Chatsworth) and Assemblyman James Ramos (D-Highland) have introduced AB 3074 the "School or athletic team names: California Racial Mascots Act."
    Schiavo Introduces Bill to Prohibit ‘Derogatory’ School Mascot Names
    Los Angeles County’s Justice, Care and Opportunities Department  in collaboration with Local Initiatives Support Corporation Los Angeles is proud to announce the 2nd Annual Pitch Competition for the cohorts of JCOD's Incubation Academy.
    March 28: JCOD Incubation Academy Helps Grassroots Non-Profits For the Second Year
    Children’s Bureau is seeking foster families and now offers two virtual ways for individuals and/or couples to learn how to help children in foster care while reunifying with birth families or how to provide legal permanency by adoption.
    April 18: Children’s Bureau Hosts Virtual Orientation
    The Sunburst track was constructed in 1887 by the Southern Pacific Railroad and was a part of the main line running between San Francisco and Los Angeles.
    Enjoy Spring With a Ride On The Sunburst Track
    California State Superintendent of Public Instruction Tony Thurmond hosted a Personal Finance Summit today where he announced his support for Assembly Bill 2927 (McCarty), legislation that would require a personal finance education course for California high school graduation.
    State Superintendent Announces Support for Personal Finance Graduation Requirement
    1847 - Probable birth date of Pico Canyon oil driller Charles Alexander Mentry [story]
    C.A. Mentry
    SCVNews.com