[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

SCVNews.com | CHLA: Obesity Causes Cancer; Inhibits a Child’s Ability to Fight It | 04-23-2013
Inside
Weather
Santa Clarita CA
Clear
Clear
75°F
 
Calendar
Today in
S.C.V. History
August 21
1961 - CalArts grad (MFA '92) and marine biologist Stephen Hillenburg, creator of Spongebob SquarePants, born in Oklahoma; developed prototype for Spongebob while studying at CalArts in 1989. Estimated net worth in 2012: $90 million [story]


| Tuesday, Apr 23, 2013

Bone marrow from a child with leukemia before (left) and after (right)chemotherapy. Chemotherapy causes an increase in the number and size of the fat cells in the marrow (white ovals). These fat cells have a large amount of an enzyme (glutamine synthetase, which shows up as brown in this picture), allowing them to produce glutamine and potentially feed nearby leukemia cells.

In a study reported in the current issue of Cancer Research, Steven Mittelman, MD, PhD, and colleagues at The Saban Research Institute of Children’s Hospital Los Angeles report that obesity substantially impairs the ability of a first-line chemotherapy to kill leukemia cells.  Not only can obesity cause cancer; this research indicates how it can significantly decrease a child’s odds of battling the disease if they get it.

“This research really shines a light on how cancer cells avoid chemotherapy,” said Brent Polk, MD, director of The Saban Research Institute.  “As childhood obesity has become a global challenge, our understanding of how to beat cancer in children is advanced by these important findings.”

Obesity is known to greatly increase one’s risk of dying from cancer. However, researchers at Children’s Hospital were the first to show that this effect may also be present in children: Obese children diagnosed with high-risk acute lymphoblastic leukemia (ALL) have a 50% greater risk of their disease recurring compared with children who are not obese.  This new study shows that obesity may impair the activity of L-asparaginase (ASNase), a first-line choice of chemotherapy drugs for treating this disease.  ASNase acts by breaking down the amino acids asparagine and glutamine, building blocks that ALL cells need to survive and proliferate.  The investigators found that fat cells produce these amino acids, and so decrease the ability of ASNase to eradicate ALL cells.

 

How Body Weight Impacts Cancer

These findings by Mittelman and colleagues are the latest installment of a frightening public health story.  In previous research using preclinical models, Mittelman has demonstrated that there are several ways in which obesity affects leukemia.  These include:

* Obesity directly accelerates the progression of leukemia

* Some chemotherapies accumulate in fat tissue, making less drug available to destroy leukemia cells

* Fat cells attract leukemia cells to areas like the bone marrow and fat tissue where they are harder to treat with chemotherapy

* Fat cells protect leukemia cells from a variety of chemotherapies – likely through secretion of survival molecules

According to Mittelman, who is also an associate professor at the Keck School of Medicine of the University of Southern California, the increased incidence and worse prognosis experienced by obese individuals with cancer translates into more than a 50% increased risk of dying from cancer compared to their lean counterparts.  Given that leukemia is the most common cancer in children and that the incidence of childhood obesity has reached epidemic proportions, there is an urgent need to intervene and prevent a potential increase in the number of children dying from leukemia.

“Our immediate goal is to develop strategies to counteract these effects of fat cells and obesity,” said Ehsan Ehsanipour, who is a master’s student in the Mittelman lab, and first author on the Cancer Research paper.  “For example, forms of ASNase which break down glutamine faster might have a better effect in obese children.” Other projected clinical studies include testing whether diet or exercise could help the prognosis of obese pediatric patients with leukemia.

This work was financially supported by the Gabrielle’s Angel Foundation, the NIH/NCI and the NIH NCRR CTSI.

 

About Children’s Hospital Los Angeles

Children’s Hospital Los Angeles has been named the best children’s hospital in California and among the top five in the nation for clinical excellence with its selection to the prestigious US News & World Report Honor Roll.  Children’s Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States, is one of America’s premier teaching hospitals and has been affiliated with the Keck School of Medicine of the University of Southern California since 1932.

For more information, visit www.CHLA.org.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

No Comments

    Leave a Comment


    SCV NONPROFIT LINKS

    NONPROFIT HEADLINES
    Monday, Aug 21, 2017
    The Santa Clarita Valley Boys & Girls Club invites everyone who shares a special connection with the club to the Alumni BBQ on Saturday afternoon, September 9.
    Friday, Aug 18, 2017
    Habitat for Humanity SFV/SCV is honored to have received a $25,000 grant from the Disabled Veterans National Foundation, which will fund trauma workshops.
    Friday, Aug 18, 2017
    The Santa Clarita Valley Senior Center’s new building campaign now only has $1.3 million remaining to raise before groundbreaking on the site can begin.
    Thursday, Aug 17, 2017
    Signups are under way for the Santa Clarita Walk to End Alzheimer’s, which offers participants an opportunity to take a healthy stroll, experience outstanding live entertainment, honor loved ones who have been affected by Alzheimer’s and raise funds to battle the debilitating disease.
    Tuesday, Aug 15, 2017
    The Boy Scouts of America Santa Clarita chapter is pairing with the Veterans Services Collaborative to add a unique twist to its annual fundraiser.

    Latest Additions to SCVNews.com
    Deputies from the Santa Clarita Valley Sheriff’s Station responded to a possible burglary call at a warehouse in the 29000 block of Avenue Sherman in Valencia Monday morning.
    SCV Deputies Investigate Reported Valencia Warehouse Burglary
    Tonight on SCV NewsBreak, a once-in-a-century solar experience took place Monday. Plus, on Saturday, dozens of people gathered in Newhall to celebrate the legacy of the old Saugus Speedway, its racers and its crew. Watch these stories and more on tonight's edition of SCV NewsBreak.
    SCV NewsBreak for Monday, August 21, 2017
    The 28th Annual Fine Art Show & Gala presented by the Santa Clarita Artists Association and the county of Los Angeles takes over Hart Hall on Saturday afternoon, October 14.
    October 14: SCAA, County’s 28th Annual Art Classic at Hart Park
    Organizers of the city of Santa Clarita's quarterly photo contest are now accepting entries for the fall 2017 competition.
    City Opens Entries for Fall 2017 Photo Contest
    The Santa Clarita Valley Boys & Girls Club invites everyone who shares a special connection with the club to the Alumni BBQ on Saturday afternoon, September 9.
    September 9: Boys & Girls Club Alumni & Friends BBQ
    Comedian and magician Fritz Coleman brings his stand-up show to Santa Clarita with an intimate, one-time performance at the Keyboard Galleria Music Center on Saturday, August 26.
    August 26: Comic Fritz Coleman Stands Up at Keyboard Galleria
    Deputies from the Santa Clarita Valley Sheriff's Station issued 38 traffic citations Friday and arrested a Newhall man on a parole violation warrant on Saturday.
    Deputies Cite Speeders, Arrest Parolee
    Lancaster JetHawks right-handed pitcher Jesus Tinoco has been named the California League Pitcher of the Week for August 14-20, 2017.
    JetHawks’ Tinoco Named Cal League Pitcher of the Week
    The Los Angeles Dodgers have acquired outfielder Curtis Granderson and cash considerations from the New York Mets in exchange for a player to be named later or cash considerations.
    Dodgers Aqcuire Outfielder Curtis Granderson from Mets
    The TMU Mustangs' women's volleyball home opener proved to be exactly what the doctor ordered as the hosts dispatched Lewis & Clark State College (ID) in straight sets 25-19, 25-22, 25-17.
    Lady Mustangs Dispatch Lewis & Clark in Straight Sets
    The Master's University's men's soccer team inaugurated their 2017 season with a 5-0 win over Northwest of Washington on Reese Field Saturday afternoon.
    TMU Men’s Soccer Blanks Northwest in Season Opener
    The Master’s University women’s soccer team’s 2017 record improved to 2-0 after beating the No. 8 ranked Northwest University Eagles 3-1 on Saturday morning at Reese Field.
    TMU Women’s Soccer Team Grounds Eagles 3-1 Saturday
    CalArtians Mathieu Libman (Film/Video BFA 19) and Aram Sarkisian (Film/Video BFA 17) are among the seven finalists for Student Academy Awards in the Animation category.
    Two CalArtians Named 2017 Student Academy Awards Finalists
    Western singer and songwriter John Zipperer headlines the next episode of "SCVTV Presents The OutWest Concert Series" at The MAIN in Old Town Newhall the evening of Friday, August 25.
    August 25: John Zipperer Headlines ‘SCVTV Presents The OutWest Concert Series’
    The Lancaster JetHawks clinched a franchise-record sixth consecutive winning season with their 71st victory, a 7-2 win over the Inland Empire 66ers, on Sunday afternoon at San Manuel Stadium.
    JetHawks Sweep Sixers Sunday, Secure Winning Season
    The Santa Clarita Valley Sheriff’s Station and the city of Santa Clarita launch the “Heads Up” campaign this week to combat distracted driving and increase pedestrian safety.
    City, Sheriff’s Station Launch ‘Heads Up’ Safety Campaign
    An 18-year-old man from Lancaster surrendered to the Santa Clarita Valley Sheriff’s Station’s Special Victims Unit Monday morning in connection with an alleged sexual assault earlier this month on College of the Canyons' Valencia campus.
    Suspect Arrested in Alleged COC Sexual Assault
    The Lancaster JetHawks scored seven runs in the fifth inning, propelling themselves to a 9-4 win over the Inland Empire 66ers on Saturday night at San Manuel Stadium.
    Seven-Run Fifth Inning Carries JetHawks to Win Saturday
    Hundreds of drivers were screened in a DUI checkpoint in Stevenson Ranch Friday night, but no arrests were made, CHP officials said.
    CHP DUI Checkpoint Screens Hundreds of Drivers
    1961 - CalArts grad (MFA '92) and marine biologist Stephen Hillenburg, creator of Spongebob SquarePants, born in Oklahoma; developed prototype for Spongebob while studying at CalArts in 1989. Estimated net worth in 2012: $90 million [story]
    The Santa Clarita Public Library invites residents to view the total solar eclipse on Monday, August 21 at the Old Town Newhall Library starting at 10 a.m.
    August 21: Solar Eclipse Viewing at Newhall Library
    1967 - New Town of Valencia dedicated; homes sell for $25,000 [story]
    1879 - Newhall civic leader Charles Henry Kingsburry born in Missouri [story]
    Alerted by a concerned citizen Friday, Santa Clarita Valley Sheriff's Station deputies once again rescued dogs the owner left in a car with the windows rolled up and no water.
    Deputies Break Window, Rescue Dogs Locked in Car
    40 oz. to Freedom arrives in Santa Clarita as part of its anniversary tour at Concerts in the Park at Central Park on Saturday, August 19, with showtime at 7 p.m.
    August 19: 40 Oz. to Freedom Rocks Central Park
    Two local environmental groups filed a complaint in L.A. Superior Court Thursday regarding the approved plan to provide water to the Newhall Ranch development, set to break ground in 2018.
    Environmental Groups File Complaint Against Newhall Ranch Water Plan
    County Supervisor Kathryn Barger has provided $143,000 in funding to extend the season of youth and adult swim programs offered at the Castaic Aquatic Center through October 31.
    Castaic Aquatic Center Programs Extended to October 31
    Tonight on SCV NewsBreak, Los Angeles County firefighters and government leaders welcomed back the Super Scoopers Friday morning. Plus, the Old Town Newhall Library helped get the community ready for it as well by handing out free eclipse viewing glasses. Watch these stories and more on tonight's edition of SCV NewsBreak.
    SCV NewsBreak for Friday, August 18, 2017
    CalArts alumna Audrey Chan (Art MFA 07) will host a free, all-ages interactive arts workshop in Little Tokyo on Saturday and Sunday, August 19 and 20, as part of the Japanese American Cultural & Community Center’s 2017 Nisei Week activities.
    August 19-20: Nisei Week Arts Workshop with CalArts Alum Audrey Chan
    Habitat for Humanity SFV/SCV is honored to have received a $25,000 grant from the Disabled Veterans National Foundation, which will fund trauma workshops.
    Habitat for Humanity Receives $25K Grant from Disabled Veterans
    Here are agenda highlights for the next meeting of the Los Angeles County Board of Supervisors, set for Tuesday, August 22, starting at 9:30 a.m..
    August 22: Board of Supervisors Meeting Agenda
    Ashley Olivier, a student worker at the Santa Clarita Valley Sheriff's Station, summited Mt. Whitney with her dad, a lieutenant at LASD's Monterey Park station.
    SCV Sheriff’s Station Student Worker, LASD Dad Top Mt. Whitney
    Looking to enter the win column for the first time in 2017 on day two of the Summer Slam volleyball tournament, the TMU Mustangs squared off against 11th-ranked Eastern Oregon but lost in straight sets.
    Mountaineers Spike Mustangs at Summer Slam
    Caltrans has released "Rail and the California Economy," a research report investigating how the state’s vast passenger and freight rail system contribute to California’s economy, as well as an overview of opportunities for rail to address the state’s needs and challenges in the future.
    New Report Details Rail Role in State Economy
    The Master’s University women’s soccer team soared to a 7-0 victory over the visiting Eagles from Sierra Nevada College Thursday.
    Lady Mustangs Soccer Win Opener 7-0
    The Master’s University women's volleyball team concluded their first day of HIU Summer Slam tournament play with a five-set thriller against the Southern Oregon University Raiders on Wednesday evening, dropping the fifth set 15-9.
    Lady Mustangs Fall in 5 to Raiders at HIU