[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

Inside
Weather
Santa Clarita CA
Sunny
Sunny
76°F
 
Calendar
Today in
S.C.V. History
January 18
1899 - Martin & Richard Wood buy J.H. Tolfree's Saugus Eating House, rename it Saugus Cafe [story]


[UCLA] – Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered the mechanism by which an experimental drug known as GCS-100 removes from lymphoma cells a protein that prevents the cells from responding to chemotherapy.

The discovery revives hope in a drug that had been tested in clinical trials years before but had been delayed indefinitely. The researchers hope GCS-100 can be combined with chemotherapy to create an effective treatment for diffuse large B-cell lymphoma (DLBCL), the most common and aggressive form of non-Hodgkin lymphoma, a cancer of the immune system.

The findings are published in the advance online issue of the journal Blood and will appear in a forthcoming print issue of the journal.

The UCLA researchers found that a protein called galectin-3 binds to an enzyme called CD45 on the surface of lymphoma cells. This protein–enzyme combination regulates the cancer cells’ susceptibility to chemotherapy, essentially protecting them from chemotherapy drugs.

Derived from citrus pectin, GCS-100 works outside the cancer cells to remove the protective galectin-3. Once the galectin-3 is removed, a lymphoma cell can be effectively killed by chemotherapy drugs, part of a chain reaction of programmed cancer-cell death known as apoptosis.

Although the researchers knew the drug had shown action against lymphoma cells, the finding that GCS-100 literally removed the barrier to the initiation of cell death by removing galectin-3 from the cell surface was unexpected.

“We let the results guide our ideas, and we were able to establish a mechanism for GCS-100,” said the study’s first author, Mary Clark, a graduate student researcher in pathology and laboratory medicine. “I am excited to follow the progress of GCS-100 and hope to see its use in the clinic as an adjunct therapy for lymphoma in the near future.”

Dr. Linda Baum, a professor of pathology and laboratory medicine and senior researcher on the study, said, “This drug had been abandoned because of the vagaries of the economy. My hope would be to restart this drug in clinical trials and, using this new knowledge, to include it in a more targeted lymphoma therapy.”

Early clinical trials of GCS-100 had shown no known side effects of the drug other than a mild rash in some patients, which other research has demonstrated is the result of the drug also promoting the development of T cells, which are created by the immune system to fight disease.

Funding for the research was provided by the Ron and Maddie Katz Family Foundation and the National Institutes of Health.

UCLA’s Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation’s largest comprehensive cancer centers, the Jonsson Center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2012, the Jonsson Cancer Center was once again named among the nation’s top 10 cancer centers by U.S. News & World Report, a ranking it has held for 12 of the last 13 years.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

0 Comments

You can be the first one to leave a comment.

Leave a Comment


HIGHER EDUCATION LINKS
LOCAL COLLEGE HEADLINES
Thursday, Jan 18, 2018
Following in the footsteps of her grandfather, dad, mom and several other family members, Erin Oxhorn-Gilpin always wanted to be a teacher.
Thursday, Jan 18, 2018
Kevin Young has been selected as the California Institute of the Arts (CalArts) 2018 Katie Jacobson Writer-in-Residence. Young will conduct workshops with CalArts students in the MFA Creative Writing Program and present public readings, which will be held at CalArts on Feb. 15 at 7:00 p.m. and at REDCAT in Downtown Los Angeles on Feb. 16 at 8:30 p.m.
Wednesday, Jan 17, 2018
California State University, Northridge journalism professor David Blumenkrantz documents the stories of the homeless of Los Angeles in an art exhibition titled “Street Scenes: Making the Homeless Count,” on display at the San Fernando Valley Arts and Cultural Center in Tarzana through Jan. 27.
Monday, Jan 15, 2018
College of the Canyons will host "College2Career Day" at the Valencia campus on Saturday, January 27 from 9 a.m. to 1 p.m. to give students of all ages the opportunity to explore college and career opportunities in promising industry clusters.
Monday, Jan 15, 2018
Starting Monday, February 5, parking on both the Valencia and Canyon Country campuses of College of the Canyons will not require a parking permit or pass after 2 p.m.
Keep Up With Our Facebook

Latest Additions to SCVNews.com
Here are the Santa Clarita arts-related events for Jan. 20 and Jan. 25:
Jan. 20, 25: Santa Clarita Arts Calendar
Following in the footsteps of her grandfather, dad, mom and several other family members, Erin Oxhorn-Gilpin always wanted to be a teacher.
CSUN Alumna Nabs Teacher of the Year
Legendary Band, "The Chieftains," will celebrate their 55th Anniversary with a performance at the Santa Clarita Performing Arts Center (SCPAC), Saturday, Feb. 24, at 8:00 p.m.
Feb. 24: The Chieftains 55th Anniversary Tour
SEATTLE - Amazon reviewed 238 proposals from across the U.S., Canada, and Mexico to host HQ2, the company’s second headquarters in North America.
Los Angeles on Short List of Amazon’s HQ2
The Santa Clarita Valley Sanitation District Board of Directors will hold its Regular Meeting Friday at 11:30 a.m.
Jan. 19: SCV Sanitation District Regular Meeting
Kevin Young has been selected as the California Institute of the Arts (CalArts) 2018 Katie Jacobson Writer-in-Residence. Young will conduct workshops with CalArts students in the MFA Creative Writing Program and present public readings, which will be held at CalArts on Feb. 15 at 7:00 p.m. and at REDCAT in Downtown Los Angeles on Feb. 16 at 8:30 p.m.
The New Yorker’s Poetry Editor Selected as CalArts 2018 Writer-in-Residence
LOS ANGELES – The County Interim Health Officer is issuing a Cold Weather Alert due to the National Weather Service’s forecast for low temperatures. Wind chill temperatures are expected to be below 32 degrees Fahrenheit. Affected areas include:
Cold Weather Alert Issued for SCV
1899 - Martin & Richard Wood buy J.H. Tolfree's Saugus Eating House, rename it Saugus Cafe [story]
The dismantling of a multi-state drug trafficking organization that used the U.S. Postal Service to mail packages of crystal methamphetamine and marijuana from California to traffickers in Pennsylvania since at least April 2016 - and the arrests of five leaders who spearheaded the corrupt organization, including two from the Santa Clarita Valley - were announced Wednesday by Montgomery County (Penn.) District Attorney Kevin R. Steele.
2 from SCV Netted in Major East Coast Drug Bust
With The Master's University's 2018 baseball season about to begin, TMU Sports Information Director Mason Nesbitt offers a preview.
TMU Previews Mustangs’ 2018 Baseball Season
Several CalArtians are among the Chicago-based United States Artists' annual fellowship class of 45 artists and collaboratives who will each receive an unrestricted $50,000 grant for their respective art practices.
CalArtians Among United States Artists’ New Fellowship Class
The TMU Mustangs' men's basketball team, on a 17-game winning streak, has moved up to No. 4 in the NAIA Division 1 Men's Basketball Coaches' Poll.
TMU Men’s Hoops Team Up to No. 4 in NAIA Coaches’ Poll
Tuesday night's 93-37 rout of St. Katherine University was more than just a non-conference tune-up for the TMU women's basketball team.
Master’s Women’s Hoops Team Shoots Down Firebirds
iLEAD Schools will honor College of the Canyons Chancellor Dr. Dianne Van Hook with its 'Vision in Education' award at the Santa Clarita Valley International School’s annual benefit dinner on March 10.
iLEAD to Honor COC’s Van Hook with 2018 ‘Vision in Education’ Award
Los Angeles County Fire Department firefighters quickly extinguished a 1/4-acre brush fire in Newhall early Wednesday afternoon.
Small Brush Fire in Newhall Quickly Doused
Los Angeles County Assessor Jeffrey Prang and the county Board of Supervisors have proclaimed January "Homeowners' Exemption Awareness Month" promote the county's property tax savings program.
County Officials:  January is ‘Homeowners’ Tax Exemption Awareness Month’
In an effort to provide support to local communities affected by the recent hurricanes in the Caribbean, and after the sell-out of the inaugural group on the January 20 Crown Princess sailing, Princess Cruises and Fathom Travel are adding two additional spring sailings in 2018.
Princess Adds More Caribbean Cruises for Spring 2018
California State University, Northridge journalism professor David Blumenkrantz documents the stories of the homeless of Los Angeles in an art exhibition titled “Street Scenes: Making the Homeless Count,” on display at the San Fernando Valley Arts and Cultural Center in Tarzana through Jan. 27.
CSUN Prof Uses Grant to Illuminate Homelessness in LA
Host College of the Canyons rallied from a nine-point halftime deficit to defeat the visiting Seahawks of Los Angeles Harbor College 96-82 on Saturday evening.
Cougars Win Third Straight with 96-82 Victory Over L.A. Harbor
The Los Angeles County Sheriff’s Department is stepping up bike and pedestrian safety enforcement operations in the Santa Clarita Valley today, officials announced this morning.
Deputies Step Up Pedestrian, Bike Safety Enforcement Today
Santa Clarita Valley Sheriff's Station deputies checking on businesses after hours arrested two people on drug charges in separate incidents in Canyon Country on Monday and Newhall on Tuesday.
Deputies Check Businesses After Hours, Arrest 2 on Drug Charges
A Canyon Country man was killed and three people injured in a high-speed traffic collision on Golden Valley Road at Dorothy Street in the unincorporated area of the Santa Clarita Valley late Tuesday night, according to the CHP.
High-Speed Crash in SCV Leaves 1 Dead, 3 Injured
The U.S. Justice Department is appealing a court order that blocked the Trump administration from shutting down a program that shields more than 700,000 young immigrants from deportation.
Justice Dept. to Appeal Ruling That Blocked DACA Shutdown
A Los Angeles County sheriff’s officer was arrested Tuesday and charged with taking bribes 'to oversee the delivery of narcotics,' federal prosecutors said.
Dirty LA Sheriff’s Officer Busted for Drugs, FBI Says
The cost of the first phase of California’s high-speed rail project through the state’s Central Valley has soared by 35 percent to $10.6 billion, officials disclosed Tuesday.
California Bullet Train Cost Climbs by $2.8 Billion
Dozens of attorneys general including California's filed a petition Tuesday challenging the Federal Communication Commission’s recent decision to roll back net neutrality rules.
State AG’s Sue FCC to Block Net Neutrality Rollback
1994, 4:31 a.m. - Magnitude 6.7 Northridge earthquake rocks Santa Clarita Valley [video]
More than 4,000 newborns in Los Angeles, including some in the SCV, will be sporting little red caps, instead of the traditional pink or blue, as part of the American Heart Association’s Little Hats, Big Hearts program aimed at bringing attention to heart disease.
Newborns to Sport Little Red Caps as Part of AHA Campaign
College of the Canyons Small Business Development Center (SBDC) will be hosting a two-part Business Events and Training Webinar Jan. 24 (Part 1) and Jan. 31 (Part 2) from 12:00 p.m. - 1:00 p.m.
Jan. 24, 31: Start, Grow Your E-Commerce Empire Webinar
The Santa Clarita Valley Veteran Center has found a permanent home in Newhall.
SCV Veteran Center Finds Permanent Home
The California Enterprise Development Authority will be holding a Teleconference Meeting Thursday at 10:30 a.m.
Jan. 18: CEDA Teleconference Meeting
The Oversight Board to the Former Redevelopment Agency of the city of Santa Clarita will hold its Regular Meeting Thursday at 3:30 p.m.
Jan. 18: Oversight Board to the Former Redevelopment Agency Regular Meeting
NORTHRIDGE, Calif - The 2018 CSUN Water Polo season presents the opportunity for the Matadors to take the next step.
Matadors Start 2018 Water Polo Season Ranked No. 21
Santa Clarita Valley International (SCVi), a free public charter school serving grades TK through 12, will host an informational session Thursday for current and prospective high school students in the school’s Shakespeare Theatre at 28060 Hasley Canyon Road in Castaic, the school announced Tuesday.
Jan. 18: SCVi Open House, High School Information Session
Commercials, television shows, and a short film are all being filmed in Santa Clarita this week.
Currently Filming in SCV: Shadow Wolves, Seal Team, Toyota Commercial
SACRAMENTO – Attorney General Xavier Becerra joined a bipartisan group of 18 state attorneys general Tuesday in urging Congress to advance legislation that will enable the cannabis industry to participate in the banking system in states that have legalized medicinal or adult use of cannabis.
Becerra, State AGs Press Congress to Let Cannabis Biz Use Banks