[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

Inside
Weather
Santa Clarita CA
Mostly sunny
Mostly sunny
82°F
 
Calendar
Today in
S.C.V. History
December 14
1931 - Season's first major storm deposits 9 inches of snow in Newhall, 10 in Saugus [story]


[SetPoint] – SetPoint Medical, a Valencia-based biomedical technology company developing neuromodulation therapies for inflammatory diseases, presented positive results from a first-in-human study using a neuromodulation device to treat rheumatoid arthritis (RA) Sunday at the American College of Rheumatology annual meeting in Washington, D.C.

“In contrast to immunosuppressive drugs, the neuromodulation therapy in this study used an implantable pulse generator to stimulate the vagus nerve, activating the body’s natural Inflammatory Reflex to produce a systemic anti-inflammatory effect,” said Dr. Kevin Tracey, President of Feinstein Institute for Medical Research, discoverer of the inflammatory reflex, and co-author of the ACR presentation. “The results of this study show promising clinical efficacy, and confirm a decade of foundational scientific research done by our laboratory and others.”

“This study validates neuromodulation as a breakthrough approach to treating RA and other autoimmune and inflammatory diseases,” said Anthony Arnold, chief executive officer of SetPoint Medical. “We look forward to developing safe and effective alternative therapies for a range of inflammatory diseases such as Crohn’s disease, ulcerative colitis, psoriasis, and for the inflammation that worsens diabetes and heart disease. This approach could offer patients 10 years of treatment for the cost of about 18 months of biologic therapy and would be an exciting new alternative for physicians to treat their patients.”

In this open label pilot study, eight patients with active rheumatoid arthritis despite treatment with the RA agent methotrexate, who would otherwise have been candidates for a TNF inhibitor, instead received the neuromodulation implant on the vagus nerve in their neck. The treatment was well tolerated, with one patient reporting hoarseness after implantation, a known side effect with this type of device. Improvement in RA was assessed at the six-week primary endpoint using standard measures of efficacy including the Disease Activity Score (DAS), and the American College of Rheumatology (ACR) 20 response rate.

At the primary end point, two of the eight patients in the study achieved DAS remission, and six of the eight had a positive ACR 20 response, results similar to those typically achieved in larger studies with drugs currently used to treat RA.

SetPoint is developing a novel platform to treat a variety of inflammation-mediated autoimmune diseases. The company is planning larger clinical studies in several diseases scheduled to begin in 2013.

 

About SetPoint Medical

SetPoint Medical is a privately held biomedical technology company dedicated to treating patients with debilitating inflammatory diseases using proprietary implantable neuromodulation devices.

SetPoint is developing safe and effective neuromodulation therapies for patients with inflammatory autoimmune diseases, such as Crohn’s Disease and rheumatoid arthritis. SetPoint’s novel platform consists of an implantable miniature neuromodulation device, wireless charger and iPad prescription pad application. The system uses vagus nerve stimulation to activate the body’s natural Inflammatory Reflex, which produces a potent systemic anti-inflammatory effect. The company has just completed a first-in-human open-label proof-of-concept trial in rheumatoid arthritis. The results confirm extensive preclinical studies, and show clinical efficacy comparable to leading immunosuppressive drugs. SetPoint’s approach is intended to offer patients and providers a better alternative approach for the treatment of RA and other chronic inflammatory diseases with less risk and cost than drug therapy. SetPoint is headquartered in Valencia, Ca., and investors in the company include Morgenthaler Ventures, Foundation Medicine and Topspin Partners. For more information, visit www.setpointmedical.com.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

No Comments

    Leave a Comment


    Latest Additions to SCVNews.com
    The William S. Hart Union High School District Governing Board has approved naming Dr. Collyn Nielsen as Chief Administrative Officer and Jan Hayes-Rennels as Director of Special Programs and Staff Development.
    Hart Appoints Nielsen, Hayes-Rennels to District Office Positions
    While critical fire conditions continue through Friday, the final numbers for the Rye Fire have been released.
    Officials Release Final Numbers on Rye Fire
    The William S. Hart Union High School District Governing Board held it’s annual reorganizational meeting Wednesday night, naming Steve Sturgeon as Board President.
    Steve Sturgeon Named 2018 Hart Board President
    Castaic Elementary School is collecting gently used children's clothing and toys for the victims of the Creek Fire in Sylmar.
    Local School Collecting Clothes, Toys for Creek Fire Victims
    SACRAMENTO – California Attorney General Xavier Becerra issued the following statement in response to the Federal Communications Commission’s (FCC) decision to repeal net neutrality rules instituted in 2015. These rules protect consumers' access to online content without interference or manipulation by an internet service provider:
    Becerra Condemns FCC’s Net Neutrality Ruling
    1931 - Season's first major storm deposits 9 inches of snow in Newhall, 10 in Saugus [story]
    The Sheriff’s Department and CHP will participate in a special year-end "Drive Sober or Get Pulled Over" enforcement campaign from December 15 through January 1.
    LASD, CHP Join ‘Drive Sober or Get Pulled Over’ DUI Campaign
    The Caribbean is back, better than ever, and Valencia-based Princess Cruises is offering the best fares of the season during the “Exclusively Caribbean Sale,” on 7-, 8-, 10-, 14-day sailings departing February through April 2018.
    Princess Cruises ‘Exclusively Caribbean Sale’ Offers Season’s Best Fares
    Designer and animator Jamie Tan (Film/Video BFA 15) started baking cakes and fancy French pastries as a meditative practice to help her balance the 20 credit semesters she was taking as a student at CalArts.
    Jamie Tan on Art, Baking for Rojas’ ‘Theater of Disappearance’
    CalArts School of Critical Studies faculty Janet Sarbanes recently received a grant from The Creative Capital | Andy Warhol Foundation Arts Writers Grant Program for her essay "Reframing the House of Dust: A Meditation in Many Parts."
    CalArts’ Janet Sarbanes Wins Writers Grant from Creative Capital
    Artist and CalArts alumna Carrie Mae Weems (Art BFA 81) concludes her year-long residency at New York’s Park Avenue Armory with a day-long convening of artists, writers, poets, musicians and social theorists on Sunday, Dec. 17.
    Dec. 17: Weems Wraps Year-Long NYC Residency
    Los Angeles County Registrar-Recorder/County Clerk Dean C. Logan was named winner of the 2017 Electoral Ergonomy Award at the International Electoral Awards on December 5 in Dead Sea, Jordan.
    LA County Registrar-Clerk Wins International Electoral Award
    The CSUN women's basketball team looks to extend its winning streak to four when the Matadors return home to face the Northern Arizona Lumberjacks on Monday, December 18.
    Dec. 18: CSUN Women’s Basketball Team Goes for 4
    Sport fishing permits for 2018 are now on sale from the California Department of Fish and Wildlife.
    Sport Fishing Licenses for 2018 Now on Sale
    The National Weather Service has issued a Red Flag Warning for the Santa Clarita Valley and other areas of Los Angeles, Ventura and Santa Barbara counties through Friday morning.
    Critical Fire Conditions in SCV Though Friday
    Steve Gerischer, proprietor of Larkspur Garden Design, will simplify the art of rose pruning and share tips on keeping your roses flourishing at the next installment of CSUN's CSUN-al Gardening series on Saturday, Jan. 13.
    CSUN-al Gardening to Tackle the Prickly Topic of Pruning Roses
    The Master’s University profiles 2017 men's basketball star Brock Gardner.
    TMU Basketball’s Brock Gardner – Tough Decisions, Terrific Transfer
    The list of Daktronics-NAIA Scholar-Athletes, released recently, was backloaded with four athletes from The Master’s University.
    4 TMU Men’s Soccer Players Named NAIA Scholar-Athletes
    During October, 15 junior high and high school campuses in Santa Clarita hosted a toiletries drive as part of their annual DFY in SCV community campaign.
    DFY in SCV Students Help Others in Need
    SCV Sheriff's Station deputies are still looking for two men who allegedly stole a wallet from a woman shopping in a local market, and posted images from surveillance video seeking the public's help to identify and locate the men.
    Deputies Still Seek Suspects in Theft of Shopper’s Wallet
    California Attorney General Xavier Becerra and 17 other attorneys general have called on the Trump Administration to respect the Consumer Financial Protection Bureau’s independence.
    AG’s File Brief Backing Consumer Financial Protection Bureau
    The Santa Clarita Arts Commission's next Regular Meeting is set for Thursday, Dec. 14 at 6:30 p.m. at City Hall.
    Dec. 14: Santa Clarita Arts Commission Regular Meeting
    The city of Santa Clarita's Parks, Recreation and Community Services Commission will hold its next Regular Meeting on Thursday, Dec. 14, at 3:30 p.m.
    Dec. 14: Parks, Recreation, Community Services Regular Meeting
    The nonprofit WiSH Education Foundation is out to raise $100,000 to fund improvements in Hart District school libraries.
    WiSH Foundation Seeks Funds for Hart District Libraries
    Valencia resident Kyanna Isaacson, 26, fulfills her dream of owning a Jersey Mike’s Subs restaurant today, and opens with a free sub fundraiser to benefit the nonprofit WiSH Education Foundation.
    Valencia Resident Opens Her Own Jersey Mike’s Sub Shop
    1900 - Automobile Club of Southern California founded; first car in SCV appeared 1902 [story]
    The City Council named Laurene Weste the new mayor of Santa Clarita Tuesday night.
    Laurene Weste Named Mayor for Fifth Time
    Paris, Amsterdam, Sydney – Unibail-Rodamco SE (“Unibail-Rodamco”) and Westfield Corporation (“Westfield”) announced Tuesday that Unibail- Rodamco has entered into an agreement to acquire Westfield to create the world’s premier developer and operator of flagship shopping destinations (the “Group”).
    French Real Estate Firm Buys Westfield in $16-Billion Deal
    NORTHRIDGE, Calif.—CSUN's Channon Fluker was named Madness National Mid-Major Women's Basketball Player of the Week Dec. 11.
    CSUN’s Fluker Named Player of the Week
    ​LOS ANGELES, CA Trammell Crow Company (TCC) and Clarion Partners have begun construction on The Center at Needham Ranch, a 54-acre, state-of-the-art industrial business park in Santa Clarita.
    Construction Underway at Needham Ranch
    NORTHRIDGE, Calif. - Attendees of California State University, Northridge's Matador Athletics events will be able to purchase beer and wine at home games beginning Jan. 6, 2018 with the start of the Men's and Women's Basketball Big West Conference season.
    Beer, Wine Will Soon be Available at CSUN Home Games
    A 2-acre brush fire, dubbed the Copper Fire, ignited shortly 4:35 p.m. on the 29100 block of West Hills Drive, according to a tweet from the Los Angeles County Fire Department.
    Forward Progress Stopped on 2-Acre West Hills Fire
    How do we close the graduation gap? How do we ensure students have the resources they need to succeed academically? Those are questions people in higher education — including at California State University, Northridge — have been grappling with for decades.
    CSUN Department Changing Way Students are Served After Data Sheds Some Light
    Offering more than 150 itineraries to popular bucket-list destinations all over the world, Princess Cruises has earned top honors for its cruise vacation itineraries in the Cruise Critic Annual Editors’ Picks Awards.
    Industry Experts Award Princess Cruises “Best Itineraries”