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January 18
1899 - Martin & Richard Wood buy J.H. Tolfree's Saugus Eating House, rename it Saugus Cafe [story]


Scientists used advanced genomic sequencing technology to identify a single point of infection from an animal reservoir to a human in the current Ebola outbreak in West Africa. This research has also revealed the dynamics of how the Ebola virus has been transmitted from human to human, and traces how the genetic code of the virus is changing over time to adapt to human hosts. Pardis Sabeti, M.D., Ph.D, a 2009 National Institutes of Health Director’s New Innovator honoree and her team carried out the research.

“Dr. Sabeti’s research shows the power of using genomic analysis to track emerging viral outbreaks,” said NIH Director Francis S. Collins, M.D., Ph.D. “This ability produces valuable information that can help inform public health decisions and actions.”

hhs_nih_logoThe 2014 Ebola outbreak is now the largest outbreak in history, with current estimates of 2,473 infections and 1350 deaths since it began in late December 2013 according to the World Health Organization. This outbreak is also the first in West Africa and the first to affect urban areas. There are no approved drugs for Ebola virus disease, though prompt diagnosis and aggressive supportive care can improve survival. The disease is characterized by high fever, headache, body aches, intense weakness, stomach pain, and lack of appetite. This is followed by vomiting, diarrhea, rash, impaired kidney and liver function and in some cases, internal and external bleeding.

To better understand why this outbreak is larger than previous outbreaks, Dr. Sabeti, senior associate member of the Broad Institute, Cambridge, Massachusetts, led an extensive analysis of the genetic makeup of Ebola samples from patients living in affected regions. Joined by an international team of scientists, Dr. Sabeti used advanced technology to analyze the genetics of the Ebola samples extremely rapidly and with high levels of accuracy. Using this technology, the researchers pinpointed a single late 2013 introduction from an unspecified animal reservoir into humans. Their study showed that the strain responsible for the West African outbreak separated from a closely related strain found in Central Africa as early as 2004, indicating movement from Central to West Africa over the span of a decade. Studying RNA changes occurring over the span of the outbreak suggests that the first human infection of the outbreak was followed by exclusive human to human transmissions.

While analyzing the genetic makeup of the Ebola samples, Dr. Sabeti and colleagues discovered a number of mutations that arose as the outbreak spread. Some of these mutations, termed nonsynonymous mutations, alter the biological state of the virus and may allow it to continually and rapidly adapt to human immune defenses as the outbreak continues. This feature points to the need for improved methods that will allow for close monitoring of changes in the viral genome and the impact on vaccine targets. Such monitoring, called genomic surveillance, can provide important insights into the biology of how the Ebola virus spreads and evolves. It may also allow scientists to develop improved methods to detect infection, and point the way to new and improved drug and vaccines.

Dr. Sabeti’s New Innovator Award is designed to support exceptionally creative new investigators conducting innovative and high-impact research, as part of the NIH Common Fund’s High-Risk, High-Reward program. The original focus of her research was on Lassa fever, a related but distinct hemorrhagic disease. When the Ebola outbreak began, she shifted her research focus to address this pressing challenge.

“Dr. Sabeti’s New Innovator Award provided flexibility to quickly adjust her research when the 2014 Ebola outbreak began,” said James M. Anderson M.D., Ph.D. director of the Division of Program Coordination, Planning and Strategic Initiatives at NIH. “This exemplifies how the High-Risk, High- Reward program allows researchers to tackle the most challenging and urgent scientific questions.”

The NIH Common Fund supports a series of exceptionally high impact research programs that are broadly relevant to health and disease. Common Fund programs are designed to overcome major research barriers and pursue emerging opportunities for the benefit of the biomedical research community at large. The research products of the Common Fund programs are expected to catalyze disease-specific research supported by the NIH Institutes and Centers. To learn more about the NIH Common Fund, visit http://commonfund.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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LOCAL NEWS HEADLINES
Wednesday, Jan 17, 2018
2 from SCV Netted in Major East Coast Drug Bust
The dismantling of a multi-state drug trafficking organization that used the U.S. Postal Service to mail packages of crystal methamphetamine and marijuana from California to traffickers in Pennsylvania since at least April 2016 - and the arrests of five leaders who spearheaded the corrupt organization, including two from the Santa Clarita Valley - were announced Wednesday by Montgomery County (Penn.) District Attorney Kevin R. Steele.
Wednesday, Jan 17, 2018
Small Brush Fire in Newhall Quickly Doused
Los Angeles County Fire Department firefighters quickly extinguished a 1/4-acre brush fire in Newhall early Wednesday afternoon.
Wednesday, Jan 17, 2018
Deputies Step Up Pedestrian, Bike Safety Enforcement Today
The Los Angeles County Sheriff’s Department is stepping up bike and pedestrian safety enforcement operations in the Santa Clarita Valley today, officials announced this morning.
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Latest Additions to SCVNews.com
1899 - Martin & Richard Wood buy J.H. Tolfree's Saugus Eating House, rename it Saugus Cafe [story]
The dismantling of a multi-state drug trafficking organization that used the U.S. Postal Service to mail packages of crystal methamphetamine and marijuana from California to traffickers in Pennsylvania since at least April 2016 - and the arrests of five leaders who spearheaded the corrupt organization, including two from the Santa Clarita Valley - were announced Wednesday by Montgomery County (Penn.) District Attorney Kevin R. Steele.
2 from SCV Netted in Major East Coast Drug Bust
With The Master's University's 2018 baseball season about to begin, TMU Sports Information Director Mason Nesbitt offers a preview.
TMU Previews Mustangs’ 2018 Baseball Season
Several CalArtians are among the Chicago-based United States Artists' annual fellowship class of 45 artists and collaboratives who will each receive an unrestricted $50,000 grant for their respective art practices.
CalArtians Among United States Artists’ New Fellowship Class
The TMU Mustangs' men's basketball team, on a 17-game winning streak, has moved up to No. 4 in the NAIA Division 1 Men's Basketball Coaches' Poll.
TMU Men’s Hoops Team Up to No. 4 in NAIA Coaches’ Poll
Tuesday night's 93-37 rout of St. Katherine University was more than just a non-conference tune-up for the TMU women's basketball team.
Master’s Women’s Hoops Team Shoots Down Firebirds
iLEAD Schools will honor College of the Canyons Chancellor Dr. Dianne Van Hook with its 'Vision in Education' award at the Santa Clarita Valley International School’s annual benefit dinner on March 10.
iLEAD to Honor COC’s Van Hook with 2018 ‘Vision in Education’ Award
Los Angeles County Fire Department firefighters quickly extinguished a 1/4-acre brush fire in Newhall early Wednesday afternoon.
Small Brush Fire in Newhall Quickly Doused
Los Angeles County Assessor Jeffrey Prang and the county Board of Supervisors have proclaimed January "Homeowners' Exemption Awareness Month" promote the county's property tax savings program.
County Officials:  January is ‘Homeowners’ Tax Exemption Awareness Month’
In an effort to provide support to local communities affected by the recent hurricanes in the Caribbean, and after the sell-out of the inaugural group on the January 20 Crown Princess sailing, Princess Cruises and Fathom Travel are adding two additional spring sailings in 2018.
Princess Adds More Caribbean Cruises for Spring 2018
California State University, Northridge journalism professor David Blumenkrantz documents the stories of the homeless of Los Angeles in an art exhibition titled “Street Scenes: Making the Homeless Count,” on display at the San Fernando Valley Arts and Cultural Center in Tarzana through Jan. 27.
CSUN Prof Uses Grant to Illuminate Homelessness in LA
Host College of the Canyons rallied from a nine-point halftime deficit to defeat the visiting Seahawks of Los Angeles Harbor College 96-82 on Saturday evening.
Cougars Win Third Straight with 96-82 Victory Over L.A. Harbor
The Los Angeles County Sheriff’s Department is stepping up bike and pedestrian safety enforcement operations in the Santa Clarita Valley today, officials announced this morning.
Deputies Step Up Pedestrian, Bike Safety Enforcement Today
Santa Clarita Valley Sheriff's Station deputies checking on businesses after hours arrested two people on drug charges in separate incidents in Canyon Country on Monday and Newhall on Tuesday.
Deputies Check Businesses After Hours, Arrest 2 on Drug Charges
A Canyon Country man was killed and three people injured in a high-speed traffic collision on Golden Valley Road at Dorothy Street in the unincorporated area of the Santa Clarita Valley late Tuesday night, according to the CHP.
High-Speed Crash in SCV Leaves 1 Dead, 3 Injured
The U.S. Justice Department is appealing a court order that blocked the Trump administration from shutting down a program that shields more than 700,000 young immigrants from deportation.
Justice Dept. to Appeal Ruling That Blocked DACA Shutdown
A Los Angeles County sheriff’s officer was arrested Tuesday and charged with taking bribes 'to oversee the delivery of narcotics,' federal prosecutors said.
Dirty LA Sheriff’s Officer Busted for Drugs, FBI Says
The cost of the first phase of California’s high-speed rail project through the state’s Central Valley has soared by 35 percent to $10.6 billion, officials disclosed Tuesday.
California Bullet Train Cost Climbs by $2.8 Billion
Dozens of attorneys general including California's filed a petition Tuesday challenging the Federal Communication Commission’s recent decision to roll back net neutrality rules.
State AG’s Sue FCC to Block Net Neutrality Rollback
1994, 4:31 a.m. - Magnitude 6.7 Northridge earthquake rocks Santa Clarita Valley [video]
More than 4,000 newborns in Los Angeles, including some in the SCV, will be sporting little red caps, instead of the traditional pink or blue, as part of the American Heart Association’s Little Hats, Big Hearts program aimed at bringing attention to heart disease.
Newborns to Sport Little Red Caps as Part of AHA Campaign
College of the Canyons Small Business Development Center (SBDC) will be hosting a two-part Business Events and Training Webinar Jan. 24 (Part 1) and Jan. 31 (Part 2) from 12:00 p.m. - 1:00 p.m.
Jan. 24, 31: Start, Grow Your E-Commerce Empire Webinar
The Santa Clarita Valley Veteran Center has found a permanent home in Newhall.
SCV Veteran Center Finds Permanent Home
The California Enterprise Development Authority will be holding a Teleconference Meeting Thursday at 10:30 a.m.
Jan. 18: CEDA Teleconference Meeting
The Oversight Board to the Former Redevelopment Agency of the city of Santa Clarita will hold its Regular Meeting Thursday at 3:30 p.m.
Jan. 18: Oversight Board to the Former Redevelopment Agency Regular Meeting
NORTHRIDGE, Calif - The 2018 CSUN Water Polo season presents the opportunity for the Matadors to take the next step.
Matadors Start 2018 Water Polo Season Ranked No. 21
Santa Clarita Valley International (SCVi), a free public charter school serving grades TK through 12, will host an informational session Thursday for current and prospective high school students in the school’s Shakespeare Theatre at 28060 Hasley Canyon Road in Castaic, the school announced Tuesday.
Jan. 18: SCVi Open House, High School Information Session
Commercials, television shows, and a short film are all being filmed in Santa Clarita this week.
Currently Filming in SCV: Shadow Wolves, Seal Team, Toyota Commercial
SACRAMENTO – Attorney General Xavier Becerra joined a bipartisan group of 18 state attorneys general Tuesday in urging Congress to advance legislation that will enable the cannabis industry to participate in the banking system in states that have legalized medicinal or adult use of cannabis.
Becerra, State AGs Press Congress to Let Cannabis Biz Use Banks
The 25th Anniversary of the City of Santa Clarita’s annual Cowboy Festival, presented by Heritage Sierra Medical Group, is set for Apr. 19 - Apr. 22.
Dates Set for Cowboy Festival’s 25th Anniversary
College of the Canyons, in partnership with the Santa Clarita Valley Senior Center, will host a free “Family Caregivers Essentials” workshop on Saturday, Jan. 27 at the Santa Clarita Valley Senior Center.
Jan. 27: Family Caregiver Workshop at SCV Senior Center
SACRAMENTO, Calif. - As the California High-Speed Rail Authority continues to move from the planning phase to full construction of the nation’s first high-speed rail system, the Board of Directors announced Tuesday that it has selected a new Chief Executive Officer, Brian P. Kelly, to lead the organization, effective Feb. 1.
Brian P. Kelly Named New High-Speed Rail Authority CEO
During her first 25 years in the Santa Clarita Valley, Betty served on the board of the Child and Family Center. She was also a volunteer for the American Red Cross, the American Heart Association, the SCV Chamber of Commerce, the Zonta Club of SCV, the SCV Boys and Girls Club, and the local Elks Lodge.
Seldner, 2000 SCV Woman of the Year, Dies at 94
1926 - Newhall Community Hospital, est. 1922, opens in larger, more modern hospital building at 6th & Spruce streets [story]
The cities of Santa Clarita, Piru, Fillmore, Bardsdale and Santa Paula along with National Historic Site Rancho Camulos will mark the 90th anniversary of the St. Francis Dam Disaster with special events throughout March 2018.
St. Francis Dam Disaster 90th Anniversary Events Set for March
A man arrested for allegedly burglarizing a Walmart Monday morning posted bail, then was soon arrested again for allegedly vandalizing the Valencia Library, according to officials.
Man Arrested After Alleged Walmart Burglary, Library Vandalism