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July 22
2000 - Historic Larinan house in Pico Canyon burns down [story]


hhslogoThe development of a medication to treat illness from Ebola will be accelerated under a contract with the U.S. Department of Health and Human Services’ Office of the Assistant Secretary for Preparedness and Response (ASPR). This contract supports the governmentwide response to the Ebola outbreak in West Africa.

ASPR’s Biomedical Advanced Research and Development Authority (BARDA) will provide funding as well as access to subject matter expertise and technical support for manufacturing, regulatory, and nonclinical activities through a $24.9 million, 18-month contract with Mapp Biopharmaceutical Inc., of San Diego, California. ASPR can extend the contract up to a total of $42.3 million.

Work under the contract supports the development and manufacturing of the medication ZMapp toward the goal of U.S. Food and Drug Administration approval.

“While ZMapp has received a lot of attention, it is one of several treatments under development for Ebola, and we still have very limited data on its safety and efficacy,” explained Dr. Nicole Lurie, assistant secretary for preparedness and response. “Developing drugs and vaccines to protect against Ebola as a biological threat has been a long-term goal of the U.S. government, and today’s agreement represents an important step forward.”

The Defense Threat Reduction Agency (DTRA) within the Department of Defense and the National Institute of Allergy and Infectious Diseases (NIAID) of HHS’ National Institutes of Health supported initial work on this product. To speed the development of ZMapp, BARDA will work closely with those agencies. BARDA also will work with the company to optimize and accelerate the manufacturing of ZMapp so testing can be done as soon as possible.

As part of the project funded today, Mapp Biopharmaceutical will manufacture a small amount of the drug for early stage clinical safety studies and nonclinical studies needed to demonstrate the drug’s safety and efficacy in people. Mapp Biopharmaceuticals also will work with BARDA on the manufacturing process, increasing production yields and the scale of manufacturing.

As an experimental drug, ZMapp currently is available only in very limited quantities and these steps will contribute to increasing the amount of product potentially available to treat patients with Ebola.

ZMapp is a combination of three monoclonal antibodies manufactured in tobacco plants. Monoclonal antibodies bind certain virus proteins and neutralize the virus, decreasing the amount of the virus in the body that the patient’s immune system has to fight. ZMapp has been shown to reduce mortality in mice and nonhuman primates exposed to Ebola viruses.

The project with Mapp Biopharmaceutical is the first BARDA program supporting the development of a product against viruses that cause viral hemorrhagic fever.

Even the most advanced potential therapeutics and vaccines for Ebola are entering early clinical trials. BARDA is working with other federal agencies to accelerate the development of Ebola therapeutics and vaccines and to identify ways to optimize and expand their production. BARDA is exploring whether its Centers for Innovation in Advanced Development and Manufacturing, its Fill Finish Manufacturing Network, or other measures can accelerate the manufacturing time.

BARDA is seeking additional proposals for the advanced development of antibody treatments, antiviral drugs, and vaccines against the Ebola and Marburg viruses, both of which cause viral hemorrhagic fever. Program requirements are described in BARDA’s Broad Agency Announcement BARDA-BAA-13-100-SOL-00013 at https://www.fbo.gov.

HHS is the principal federal agency for protecting the health of all Americans and providing essential human services, especially for those who are least able to help themselves. The Office of the Assistant Secretary for Preparedness and Response (ASPR) leads HHS in preparing the nation to respond to and recover from adverse health effects of emergencies, supporting communities’ ability to withstand adversity, strengthening health and response systems, and enhancing national health security.

Within ASPR, the Biomedical Advanced Research and Development Authority (BARDA) develops and procures medical countermeasures – vaccines, medicines, diagnostics and medical equipment – that address the public health and medical consequences of chemical, biological, radiological, and nuclear (CBRN) accidents, incidents and attacks, pandemic influenza, and emerging infectious diseases.

For more information about advanced research and development of medical countermeasures, visit www.medicalcountermeasures.gov. Contract opportunities and awards are announced at www.fbo.gov.

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SCV NewsBreak
LOCAL NEWS HEADLINES
Friday, Jul 20, 2018
Court: Chiquita Landfill Must Comply with CUP, Pay County $12 Mil.
The L.A. County Superior Court on July 17 sided with Los Angeles County and dismissed a portion of Chiquita Canyon LLC's complaint, which challenged 13 conditions of the county's conditional use permit governing how the landfill operates, Supervisor Kathryn Barger announced Friday.
Friday, Jul 20, 2018
Suspected Van Thieves Crash, Rupture Gas, Water Lines in Valencia
Four men allegedly stole a van and crashed it at Cinema Drive and Valencia Boulevard late Friday afternoon, breaking gas and water lines and snarling rush-hour traffic in the center of the city.
Friday, Jul 20, 2018
SCV Water Board Trims Own Meeting Attendance Pay
The Santa Clarita Valley Water Agency's board of directors voted in its Tuesday meeting to revise its per-diem payment policy for board members attending industry-related meetings and conferences.
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Latest Additions to SCVNews.com
2000 - Historic Larinan house in Pico Canyon burns down [story]
1952 - 7.5-magnitude Kern County earthquake devastates Tehachapi; damage spread from San Diego to Las Vegas [story]
The L.A. County Superior Court on July 17 sided with Los Angeles County and dismissed a portion of Chiquita Canyon LLC's complaint, which challenged 13 conditions of the county's conditional use permit governing how the landfill operates, Supervisor Kathryn Barger announced Friday.
Court: Chiquita Landfill Must Comply with CUP, Pay County $12 Mil.
Four men allegedly stole a van and crashed it at Cinema Drive and Valencia Boulevard late Friday afternoon, breaking gas and water lines and snarling rush-hour traffic in the center of the city.
Suspected Van Thieves Crash, Rupture Gas, Water Lines in Valencia
The Los Angeles County Arts Commission has announced $4,518,000 in two-year grants to 216 nonprofit arts organizations through its Organizational Grant Program, and the Santa Clarita Philharmonic Orchestra and the Santa Clarita Shakespeare Festival are among the grantees.
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The Santa Clarita Valley Water Agency's board of directors voted in its Tuesday meeting to revise its per-diem payment policy for board members attending industry-related meetings and conferences.
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SCV Heat Alert Called for Monday, Tuesday
The Lancaster JetHawks jumped out to a 4-0 lead, but two late home runs from Stockton's Sandber Pimentel led the Ports to victory in a 5-4 final on Thursday night at Banner Island Ballpark.
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