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April 23
1986 - COC board votes to allow Argentine cliff swallows to nest forever on sides of buildings [story]


hhs_nih_logoA clinical trial of a new investigational vaccine designed to protect against West Nile Virus infection will be sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

The experimental vaccine was discovered and developed by scientists at the Oregon National Primate Research Center at Oregon Health & Science University (OHSU) in Portland. The scientists were funded with a $7.2 million grant from NIAID, awarded in 2009. The new vaccine is being tested in a Phase 1 clinical trial at Duke University in Durham, North Carolina, one of NIAID’s Vaccine and Treatment Evaluation Units (VTEUs).

Most commonly spread through the bite of infected mosquitoes, West Nile Experimental West Nile Vaccine Being Tested on Humansirus (WNV) infection is typically a seasonal epidemic in the United States that begins in late spring or early summer and continues into the fall. Last year, 2,205 cases of WNV disease and 97 related deaths were reported in the United States.

mosquitobitingThe majority of people infected with WNV will show no symptoms. Roughly 1 in 5 people who are infected will display relatively mild symptoms, such as fever, headache, body aches, nausea, and vomiting. Only about 1 in 150 people infected with WNV will develop a serious neurologic illness, such as encephalitis or meningitis. Most people with WNV disease recover completely, but the elderly and other immunocompromised individuals are at higher risk for long-term side effects or death resulting from infection. From 1999 to 2014, a total of 41,762 cases of WNV disease have been confirmed in the United States, including 1,765 deaths. Although an effective veterinary vaccine against WNV is available, no human vaccine has been approved for commercial use.

“Since first appearing in the United States in 1999, West Nile Virus has emerged as an important health threat in this country. NIAID is committed to research efforts to advance a preventive vaccine that could protect people against West Nile Virus infection,” said NIAID Director Anthony S. Fauci, M.D.

The OHSU research team, led by senior scientist Mark Slifka, Ph.D., created the investigational vaccine, called HydroVax-001, with a novel, hydrogen peroxide-based process that renders the virus inactive while still maintaining key immune-system triggering surface structures. The virus used to make the vaccine is inactivated and cannot cause WNV infection. Because it is inactivated, the experimental vaccine likely could be used in a diverse population, including immunologically vulnerable groups, such as the elderly.

In preclinical studies, the test vaccine was effective at protecting mice against a lethal dose of West Nile Virus. In mice, the vaccine elicited neutralizing antibody responses and CD8+ T cells, which bind to and kill infected cells.

The clinical trial will test the safety of the vaccine as well as its ability to produce an immune response. The trial will enroll 50 healthy men and women, ages 18 to 50 years. The volunteers will be randomly assigned to receive a low dose of the vaccine (one microgram), a higher dose (four micrograms), or a placebo. Forty volunteers will receive the investigational vaccine; 10 study volunteers will receive the placebo. Each participant will receive an intramuscular injection twice: on day one and on day 29. Study participants will be followed for 14 months.

The clinical trial is being conducted by researchers at Duke University, one of nine NIAID VTEUs. Enrollment is expected to be completed by December 2015.

Additional information about the clinical trial is available at ClinicalTrials.gov using the identifier NCT02337868. For more information about NIAID’s West Nile Virus research, visit our website.

NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

 

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SCV NewsBreak
LOCAL NEWS HEADLINES
Sunday, Apr 22, 2018
Stars Share Spotlight as Cowboy Festival Turns 25
Veterans of the Santa Clarita Cowboy Festival stage were honored Saturday night as the city celebrated the festival’s silver anniversary at William S. Hart Park in Newhall.
Friday, Apr 20, 2018
Newhall Woman Charged with Murder of Boyfriend
A 25-year-old woman has been charged with shooting her boyfriend to death in the parking lot of a Canoga Park bar, the Los Angeles County District Attorney’s Office announced Friday.
Friday, Apr 20, 2018
April 21: Gala Celebrates Cowboy Festival 25th Anniversary
Good seats are still available but going fast for the Santa Clarita Cowboy Festival's 25th-anniversary gala celebration at Hart Hall on Saturday, April 21 from 8 p.m. to 9:30 p.m.
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Latest Additions to SCVNews.com
1986 - COC board votes to allow Argentine cliff swallows to nest forever on sides of buildings [story]
Veterans of the Santa Clarita Cowboy Festival stage were honored Saturday night as the city celebrated the festival’s silver anniversary at William S. Hart Park in Newhall.
Stars Share Spotlight as Cowboy Festival Turns 25
1974 - Gov. Ronald Reagan speaks at dedication of COC's first permanent building, the William G. Bonelli Instructional Resource Center [story]
1994 - Valencia Mercedes co-owner Eddie Murray sets MLB record for switch-hit home runs in games (11 times) [story]
A 25-year-old woman has been charged with shooting her boyfriend to death in the parking lot of a Canoga Park bar, the Los Angeles County District Attorney’s Office announced Friday.
Newhall Woman Charged with Murder of Boyfriend
The Herb Alpert School of Music at CalArts will host the legendary rapper Kurtis Walker, aka Kurtis Blow, as part of its visiting artist series, on Monday and Tuesday, April 23 and 24, from 2 p.m. to 4 p.m. each day.
Rapper Kurtis Blow Is CalArts’ Visiting Artist for Music
The five filmmakers selected for California State University, Northridge’s 28th annual Senior Film Showcase on May 2 are women, and their stories reflect the rich diversity of perspectives that make up America.
May 2: CSUN to Spotlight Hollywood’s Future Filmmakers
The CalArts School of Theater presented the graduating class of the Acting Program in a bi-coastal Actors Showcase at the Colony Theater in Burbank on Monday, April 16.
CalArts Actors Showcase Celebrates Graduating Class
TMU coach Zach Schroeder has said for weeks that this week's track meet in Azusa, California, would be crucial as far as Mustangs advancing to NAIA nationals.
Two Mustangs Qualify for NAIA Track Nationals
Heath Holder delivered four shutout innings in the first start of his professional career, but the JetHawks dropped the series opener to the Inland Empire 66ers, 8-3, on Thursday night at San Manuel Stadium.
Holder Strong in Season Debut, But JetHawks Fall 8-3
Santa Clarita-based Carnival Corporation and plc, the world’s largest leisure travel company, has made several key senior executive appointments and promotions to serve its multiple brands and business units globally.
Carnival Names New Execs for 4 Cruise Lines
The Saugus Union School District has set its 2018 open house schedule to provide opportunities for Saugus parents to visit their children’s classrooms to view the amazing work accomplished this school year.
Saugus School District Slates 2018 Open House Events
SCV Kids Consignment, part of the LA Kids Consignment family of sales, continues its spring sale Saturday and Sunday, April 21-22 in Castaic from 9 a.m. to 5 p.m. each day.
April 21-22: SCV Kids Consignment Spring Sale in Castaic
The Castaic Union School District Board of Trustees unanimously approved a three-percent raise and a bonus for its educators at last week’s board meeting.
Castaic School Board OKs First Teacher Pay Raise in 12 Years
The next meeting of the Los Angeles County Board of Supervisors is set for Tuesday, April 24, starting at 9:30 a.m.
April 24: LA County Board of Supervisors Meeting
Good seats are still available but going fast for the Santa Clarita Cowboy Festival's 25th-anniversary gala celebration at Hart Hall on Saturday, April 21 from 8 p.m. to 9:30 p.m.
April 21: Gala Celebrates Cowboy Festival 25th Anniversary
The Final Environmental Assessment, draft Decision Notice, and Finding of No Significant Impact for the San Gabriel Mountains National Monument Plan are complete, and a 45-day official objection period begins Friday before one of three options is chosen.
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A Stevenson Ranch resident is missing more than $9,000 in jewelry, and suspects her roommates, Santa Clarita Valley Sheriff's Station Deputy Kevin Duxbury reported in a post on the station's Facebook page
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Monday, April 23 is the deadline to apply for street pole Hometown Heroes military banners to be displayed by the city of Santa Clarita on Memorial Day, saluting actively serving military members from the Santa Clarita Valley.
April 23: Deadline to Order Hometown Heroes Military Banners
The Hart High School Baseball Program and the Boys & Girls Club of Santa Clarita Valley will again present Hart Baseball Bingo Night at the Newhall club on Saturday, May 12, starting at 5 p.m.
May 12: Bingo Night Fundraiser for Hart Baseball Program
California State University will not increase tuition for the 2018-19 academic year, but will continue to fight for increased funding to meet its current needs, according to Chancellor Timothy P. White.
California State University Decides Not to Increase 2018 Tuition
Wednesday, May 2 is the deadline to apply for one of 23 positions with the Santa Clarita Library.
May 2: Deadline to Apply for 23 Santa Clarita Library Jobs
1874 - First train out of L.A. to reach new town of San Fernando; Newhall 2 years later [story]
NORTHRIDGE - CSUN beach volleyball honored its first seniors Thursday, just after the Matadors improved to 15-6 with a 5-0 sweep over Cal State Los Angeles at the CSUN Beach Volleyball Facility.
Matadors Celebrate Senior Day, Sweep of UC Irvine
Parents from Albert Einstein Academy for Letters, Arts, and Sciences were notified Wednesday that Einstein will surrender its charter from the Acton Agua Dulce Unified School District and shutter its campuses.
Einstein Academy to Close Charter Schools
NORTHRIDGE - CSUN Baseball (17-19, 5-4 BWC) resume Big West play this weekend with a three-game series against UC Irvine at Matador Field.
Matadors Resume Big West Play with 3 Game Set Against UC Irvine
The California Enterprise Development Authority will hold a teleconference meeting Thursday, April 26, at 10:30 a.m.
April 26: California Enterprise Development Authority Teleconference Meeting
The Santa Clarita City Council will be holding its regular meeting Tuesday, April 24, at 6:00 p.m.
April 24: City Council Regular Meeting
Solo Flight Swing is a Southern California-based western swing band that performs hot western-swing, dixie, bop, originals, and covers.
April 20: Solo Flight Swing at The MAIN
The County of Los Angeles Department of Animal Care and Control (DACC) celebrates National Volunteer Appreciation Week starting on April 15 - April 22.
Volunteers of the Year Recognized by County Animal Control
In partnership with the Santa Clarita Valley Senior Center and Alzheimer's Greater Los Angeles, College of the Canyons will be offering the next workshop for family caregivers.
April 28: Family Caregivers Workshop
Once again, the Paseo Aquatics Club entered the pool undermanned and underdogs, and came away with an impressive 15th place finish against 75 other teams, many of which were double and triple in size, at the recent Speedo Short Course Far Western Championships hosted by Santa Clara Swim Club.
Underdogs Paseo Aquatics Club Holds Their Own in Top State Meet
A reckless driver on Railroad Avenue led to a pursuit that landed four suspects in custody on Wednesday.
Newhall Pursuit Ends with Four Suspects in Custody
LANCASTER - Rancho Cucamonga homered five times Wednesday night as Lancaster fell, 11-4, in the series finale at The Hangar. Rancho’s Rylan Bannon became the second California League player this season to hit three home runs in a game.
JetHawks Fall to Quakes in Series Finale
Here is the Stevenson Ranch Crime Information and Public Safety Report for the week of April 9 - 15:
Crime Blotter: Assault, Grand Theft Auto, Burglary in Stevenson Ranch
SACRAMENTO - California State Auditor released Thursday an audit requested by Senator Scott Wilk, R - Antelope Valley, last spring concerning homelessness in California and specifically the Los Angeles Homeless Services Authority's administration of public funds.
Audit on Homelessness Highlights Need for Improvement, Services