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October 24
1992 - Dedication of Santa Clarita's first Metrolink station (Santa Clarita Station) [brochure]
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Anopheles funestus, a malaria-transmitting mosquito | Photo: CDC

Anopheles funestus, a malaria-transmitting mosquito | Photo: CDC

A candidate malaria vaccine is safe and protects against infection in adults, according to the results of an early-stage clinical trial.

Anopheles funestus, a malaria-transmitting mosquito. Image by James Gathany, Dr. Frank Collins, University of Notre Dame, courtesy of CDC.

Malaria is one of the most common infectious diseases in the world and an enormous public health problem. It kills hundreds of thousands of people each year, most of them young children in Sub-Saharan Africa. Currently, there is no effective malaria vaccine.

Malaria is caused by the Plasmodium parasite. Infection occurs when a person is bitten by a mosquito harboring 1 of 4 species of Plasmodium.

The PfSPZ Vaccine, developed by scientists at Sanaria Inc., is composed of a live but weakened version of Plasmodium falciparum, the most deadly malaria-causing parasite. The parasites are weakened by exposing them to radiation when they’re in the infective stage of development, called sporozoites. For many years, it wasn’t possible to purify these sporozoites from the mosquito. But scientists recently figured out how to isolate the weakened sporozoites so that they can be given in an injected vaccine.

A Phase I trial of the PfSPZ Vaccine took place at the NIH Clinical Center in Bethesda, Maryland. Led by Dr. Robert A. Seder at the Vaccine Research Center of NIH’s National Institute of Allergy and Infectious Diseases (NIAID), researchers enrolled 57 healthy adults, ages 18-45, with no previous malaria infection.

Forty participants received the PfSPZ Vaccine and 17 didn’t. The vaccine recipients were split into different dosage groups. Each group received 2-6 intravenous injections of increasing doses given 4 weeks apart. The results appeared online in Science on August 8, 2013.

After vaccination, participants were monitored closely for 7 days. No severe side effects or malaria infections developed. Those who received a higher total dosage of the vaccine had a greater immune system response.

To evaluate the protection provided by the PfSPZ Vaccine, the scientists collaborated with the Walter Reed Army Institute of Research and the Naval Medical Research Center. Participants were exposed to 5 bites by P. falciparum-infected mosquitoes 3 weeks after vaccination. They were then monitored for 7 days and tested for infection. Those who were diagnosed with malaria were treated with anti-malarial drugs and cured.

The researchers found that only 3 of the 15 who received the highest doses of the vaccine became infected from the mosquito bites. Of the 6 participants who received all 5 injections using this highest dose, none were infected. In contrast, 16 of 17 participants in the lower dosage group and 11 of 12 who received no vaccine became infected.

“Scientists and health care providers have made significant gains in characterizing, treating and preventing malaria; however, a vaccine has remained an elusive goal. We are encouraged by this important step forward,” says NIAID Director Dr. Anthony S. Fauci.

Several follow-up studies are now planned. They include exploring how long protection lasts and whether the vaccine could protect against other strains of P. falciparum. Among the future challenges is that this vaccine must be injected intravenously—a rare delivery route for vaccines—and stored in liquid nitrogen. This would require new infrastructure, especially in rural, developing regions where the vaccine would be most needed.

– National Institutes of Health

 

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1 Comment

  1. Dee Reponte says:

    Keep your area clean and also use an effective mosquito repellent just like the one we found on Amazon called Sweetly Citron. You can spray it even on your clothes.

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SCV NewsBreak
LOCAL NEWS HEADLINES
Friday, Oct 23, 2020
Friday COVID-19 Roundup: 296,821 L.A. County Cases, 7,000 in SCV
The Los Angeles County Department of Public Health on Friday confirmed 23 new deaths and 2,773 new positive cases of COVID-19, including 56 new cases in the Santa Clarita Valley.
Friday, Oct 23, 2020
Sixth Round of ‘Homekey’ Funding Includes $24M for L.A. County
California Governor Gavin Newsom on Friday announced a major injection of new Homekey funding made possible by the Legislature to expand and support the state program, helping thousands of families experiencing or at risk of homelessness find permanent, long-term housing solutions.
Friday, Oct 23, 2020
Santa Clarita 2020 ‘State of the City’ Highlights Resilience Amid Challenges
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Latest Additions to SCVNews.com
1992 - Dedication of Santa Clarita's first Metrolink station (Santa Clarita Station) [brochure]
brochure
The Los Angeles County Department of Public Health on Friday confirmed 23 new deaths and 2,773 new positive cases of COVID-19, including 56 new cases in the Santa Clarita Valley.
Friday COVID-19 Roundup: 296,821 L.A. County Cases, 7,000 in SCV
California Governor Gavin Newsom on Friday announced a major injection of new Homekey funding made possible by the Legislature to expand and support the state program, helping thousands of families experiencing or at risk of homelessness find permanent, long-term housing solutions.
Sixth Round of ‘Homekey’ Funding Includes $24M for L.A. County
The Santa Clarita City Council has posted its agenda for a regular meeting in Council Chambers at City Hall on Tuesday, October 27.
Oct. 27 Meeting Agenda: Santa Clarita City Council
The city of Santa Clarita has received the Certificate of Achievement for Excellence in Financial Reporting from the Government Finance Officers Association of the United States and Canada.
City of Santa Clarita Earns National Financial Reporting Award
The Santa Clarita Valley Sheriff's Station will host a National Drug Takeback Day event on Saturday, October 24, between 10 a.m. and 2 p.m.
Oct. 24: SCV Sheriff’s Station to Host Drug Takeback Day
City of Santa Clarita officials delivered the 2020 State of the City event Thursday in true COVID-19-era format: virtually, while shining a light on local essential workers who have toiled tirelessly since the onset of the pandemic.
Santa Clarita 2020 ‘State of the City’ Highlights Resilience Amid Challenges
Governor Gavin Newsom has announced the retirement of California Highway Patrol Commissioner Warren Stanley, and the appointment of Deputy Commissioner Amanda Ray to succeed Stanley.
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Parolee, Woman Arrested in Valencia on Felony Drug, Weapon Charges
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Southern Hotel
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FEMA Application Now Open for L.A. County Residents Affected by Bobcat Fire
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Los Angeles County is providing a second opportunity for financial assistance to businesses that have been disproportionately impacted by the COVID-19 pandemic and have been allowed to reopen by the State, but ordered to remain closed by the County of Los Angeles Health Officer Order as of Sept. 4, 2020.
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The Los Angeles County Department of Public Health confirmed Thursday 18 new deaths and 3,600 new cases of COVID-19 countywide, including 6,944 total cases in the Santa Clarita Valley and a new fatality in the city of Santa Clarita.
Thursday COVID-19 Roundup: 73rd SCV Death; Local Cases Up to 6,944
SCV Water is undertaking multiple planning efforts designed to effectively manage the water supply for our customers, ensuring they have access to reliable water today and tomorrow.
SCV Water Undertaking Multiple Planning Efforts to Enhance Water Reliability
With L.A. County’s Project Roomkey coming close to an end, Bridge to Home officials announced Thursday a new initiative to house more than two dozen local homeless individuals, but it will require help from the community
Bridge to Home’s New Initiative Pledges to House 30 Homeless People by January 5
Santa Clarita Artists Association will hold its last virtual oil workshop of the year on Sunday, Nov. 15, from 3:00 p.m. - 6:00 p.m., with Rich Gallego, entitled, "Using a Modified Zorn Palette to Create Harmonious Landscapes."
Nov. 15: Last SCAA Virtual Oil Painting Workshop of 2020 with Rich Gallego
The Dr. Dianne G. Van Hook University Center will host a virtual open house event on Friday, Oct. 30 for prospective students interested in earning a bachelor’s or master’s degree through the center’s partner institutions.
Oct. 30: Dr. Dianne G. Van Hook University Center Virtual Open House
Santa Clarita homeless task force members are exploring options to start a local overnight parking program akin to those in Santa Barbara and Los Angeles.
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The William S. Hart Union High School District will likely not return to campus until January, Superintendent Mike Kuhlman said during the district’s governing board meeting Wednesday.
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Oct. 24: Free Household Hazardous Waste & E-Waste Recycling Roundup
California theme parks are considering legal action to receive permission to reopen, following state guidelines announced Tuesday that keep venues such as Six Flags Magic Mountain closed for an unknown amount of time.
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