[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

Inside
Weather
Santa Clarita CA
Clear
Clear
68°F
 
Calendar
Today in
S.C.V. History
October 15
1939 - Second, larger OLPH Catholic Church dedicated on site of first (10th & Walnut, Newhall) [story]


hhs_nih_logoA large clinical trial to assess the safety and efficacy of two experimental vaccines to prevent Ebola virus infection is now open to volunteers in Liberia. The trial is being led by a recently formed Liberia-U.S. clinical research partnership and is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The Partnership for Research on Ebola Vaccines in Liberia or PREVAIL, a Phase 2/3 study, is designed to enroll approximately 27,000 healthy men and women aged 18 years and older.

One vaccine candidate, cAd3-EBOZ, uses a chimpanzee-derived cold virus to deliver Ebola virus genetic material from the Zaire strain of virus causing the outbreak in Liberia. Published interim results from a Phase 1 trial of this vaccine, which was co-developed by NIAID scientists and GlaxoSmithKline, provided necessary safety information and showed that it prompted immune responses to the outer coat of Ebola virus. The other candidate, VSV-ZEBOV, employs vesicular stomatitis virus, an animal virus that primarily affects cattle, to carry an Ebola virus gene segment. The VSV-ZEBOV vaccine was developed by the Public Health Agency of Canada and licensed to NewLink Genetics Corporation through its wholly owned subsidiary BioProtection Systems Corporation. Phase 1 trial results of this vaccine also provided safety information and showed that it prompted immune responses to the outer coat of Ebola virus. These results have not yet been published but were made available to the regulatory bodies reviewing the study.

“The scale of the current Ebola outbreak in West Africa is unprecedented, and specific medical countermeasures are needed for this and future outbreaks,” said NIAID Director Anthony S. Fauci, M.D. “It is imperative that any potential countermeasures, including vaccines, be tested in a manner that conforms to the highest ethical and safety standards in clinical trials designed to provide a clear answer to the question of whether a candidate vaccine is safe and can prevent infection. This trial is designed to provide such answers.”

In addition to healthy adults in the general population, the trial will seek volunteers from groups at particular risk of Ebola infection, including health care workers, communities with ongoing transmission, contact tracers and members of burial teams. Social mobilization and community engagement activities began in Montserrado County, where the Liberian capital Monrovia is located, before the trial started and will continue in order to successfully recruit thousands of participants.

Participants will be assigned at random to one of three equal-sized groups. Volunteers in one group will receive a placebo (saline) injection, while the others will receive a single injection of either the cAd3-EBOZ vaccine or the VSV-ZEBOV vaccine. In addition to including a placebo group, the trial will be double-blinded, meaning that neither volunteers nor staff will know whether a vaccine or placebo was administered. A randomized, double-blind, placebo-controlled trial is considered the “gold standard” in clinical research. All participants will be advised on how to minimize the risk of becoming infected with Ebola virus and will be contacted by study staff about one week after the injection and then monthly for the duration of the study, which is currently expected to last about twelve months.

Given the current decline in the number of new Ebola cases in Liberia, study investigators anticipate the need for flexibility in the conduct and design of the trial to address the changing nature of the outbreak.

The co-leaders of the trial are Stephen B. Kennedy, M.D., MPH, secretary-general of the Liberia College of Physicians and Surgeons; Fatorma Baloy, Ph.D., director, Liberian Institute for Biomedical Research; and H. Clifford Lane, M.D., NIAID’s deputy director for clinical research and special projects. The pharmaceutical company GlaxoSmithKline (Research Triangle Park, North Carolina) will supply the cAd3-EBOZ investigational vaccine; Merck (Kenilworth, New Jersey) and NewLink Genetics, Inc. (Ames, Iowa) will supply the VSV-ZEBOV candidate. Additional information about the study is available at ClinicalTrials.gov using the identifier NCT02344407.

NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

No Comments

    Leave a Comment


    SCV NewsBreak
    LOCAL NEWS HEADLINES
    Monday, Oct 15, 2018
    SCE Monitoring High Wind, May Kill Power to Avert Downed-Line Fires
    Southern California Edison is monitoring weather conditions and has additional crews at the ready to respond to possible power outages and dangerous wildfire conditions due to Santa Ana winds and low humidity predicted through Tuesday night.
    Monday, Oct 15, 2018
    Red Flag Warning Flies in SCV Through Tuesday Night
    A red flag warning issued due to gusty high winds and low humidity will remain in effect through 8 p.m. Tuesday, according to the National Weather Service.
    Monday, Oct 15, 2018
    SCV Deputies Arrest Nearly 70 in Crime Suppression Operations
    Deputies from the Santa Clarita Valley Sheriff's Station have arrested nearly 70 people in a series of crime suppression operations during October, according to station officials.
    Keep Up With Our Facebook

    Latest Additions to SCVNews.com
    A free LifeForward workshop hosted by Zonta Club of Santa Clarita Valley is scheduled at Savia Community Center, 23780 Newhall Ave in Newhall on Saturday, Oct. 20, from 10 a.m. to 12:30 p.m.
    Oct. 20: Life Coach Laura Cazares to Speak at Zonta Workshop
    The Child & Family Center's 15th Annual Kid Expo will be held at Golden Valley High School on Sunday, Oct. 21, from 11 a.m. to 4 p.m.
    Oct. 21: Kid Expo at GVHS to Benefit Child & Family Center
    Los Angeles County had higher influenza activity in the 2017–18 season (Oct. 1, 2017–May 13, 2018) than the previous five influenza seasons, according to public health officials' Influenza Season Summary.
    More County Influenza Deaths in 2017-18 Than in 5 Previous Seasons
    CSUN students will explore the collective consciousness of men of color at CSUN’s biannual Men of Color Enquiry and Student Research Poster Session on Friday, Oct. 26, from 11 a.m. to 1:30 p.m.
    Oct. 26: CSUN Looks to Inspire Men of Color with Research Session
    The Master's men's soccer team's 1-0 win over the Warriors in Santa Barbara Saturday was a sweet one for The Master's University head coach Jim Rickard and his Mustangs.
    TMU Men’s Soccer Team Edges Westmont Behind Garcia Sosa Goal
    The Master's University's women's soccer team suffered a 2-0 loss to No. 11 Westmont on Saturday in Santa Barbara.
    TMU Women’s Soccer Team Falls to Westmont on the Road
    Despite The Master's University women's volleyball team's 3-0 loss in Santa Barbara, ending a 12-match winning streak, the No. 11 Mustangs remain in first place in GSAC standings.
    TMU Women’s Volleyball Win Streak Snapped in Santa Barbara
    Celebrate the harvest season with storytelling through dance and drums under the oak trees at Placerita Canyon in the Nature Center's outdoor amphitheater on Saturday, Nov. 3 from 3 p.m. to 5 p.m.
    Nov. 3: Free Volta Drum Dance at Placerita Canyon Nature Center
    The city of Santa Clarita has updated the list of productions shooting in the city and the Santa Clarita Valley for the week of Oct. 15-21, 2018.
    Features, TV Shows, Spots Now Filming in SCV
    Southern California Edison is monitoring weather conditions and has additional crews at the ready to respond to possible power outages and dangerous wildfire conditions due to Santa Ana winds and low humidity predicted through Tuesday night.
    SCE Monitoring High Wind, May Kill Power to Avert Downed-Line Fires
    A red flag warning issued due to gusty high winds and low humidity will remain in effect through 8 p.m. Tuesday, according to the National Weather Service.
    Red Flag Warning Flies in SCV Through Tuesday Night
    Deputies from the Santa Clarita Valley Sheriff's Station have arrested nearly 70 people in a series of crime suppression operations during October, according to station officials.
    SCV Deputies Arrest Nearly 70 in Crime Suppression Operations
    Ahead of Election Day Nov. 6, airwaves and mailboxes across California overflow with expensive campaign advertisements, among them ads urging yes or no votes on state ballot measures.
    Century-Old California Direct-Democracy System Now ‘Pay-to-Play’
    John Bulinski has been appointed the director of the California Department of Transportation's District 7, and will oversee the freeway system in Los Angeles and Ventura counties, Caltrans announced Monday.
    John Bulinski Named Caltrans Director for LA, Ventura Counties
    1939 - Second, larger OLPH Catholic Church dedicated on site of first (10th & Walnut, Newhall) [story]
    Here is the Week 8 roundup of Santa Clarita Valley football scores.
    Santa Clarita Valley Football Roundup
    1980 - Phillies beat Royals in Game 1 of World Series; Hart grad Bob Walk is winning pitcher [story]
    1876 - Town of Newhall founded at Bouquet Junction (moved 2 years later to present location) [story]
    County Supervisor Kathryn Barger has introduced a motion to bring forward a public health-centered effort to address the emergence of diseases that have impacted the county, especially among the homeless population.
    Barger Urges Effort to Curb Spread of Disease in County Homeless Population
    CalArts student Hanna Kim (Film/Video BFA 19) won the gold medal for Animation (Domestic Film Schools) during the Academy of Motion Picture Arts and Sciences' 45th Student Academy Awards ceremony Thursday night.
    CalArts’ Hanna Kim Wins Gold in 45th Student Academy Awards
    Here's a look at how The Master's University's sports teams rank in the latest polls.
    TMU Mustangs Sports: A Peek at the Polls
    The Valley Industry Association will present a California State Assembly 38th District Candidate Forum at its monthly business luncheon at Valencia Country Club on Tuesday, Oct. 16, starting at 11:45 a.m.
    Oct. 16: Assembly 38th District Candidates to Face Off at VIA Forum
    Detectives from the Santa Clarita Valley Sheriff's Station arrested a man in Oakland suspected of robbing a business in Castaic on Oct. 5, according to station authorities.
    SCV Detectives Arrest Castaic Robbery Suspect in Oakland
    The next meeting of the Los Angeles County Board of Supervisors is set for Tuesday, Oct. 16, starting at 9:30 a.m.
    Oct. 16: LA County Board of Supervisors Meeting
    Los Angeles County election officials are alerting residents about a misleading robocall now circulating that wrongly claims there is an error in one of the ballot titles for the Nov. 6 General Election.
    Voter Alert: Beware of Robocalls Making False Statements
    The California Highway Patrol has received a federal grant to develop the Get Educated and Ride Safe, or GEARS, program to promote motorcycle safety and awareness.
    CHP Receives Grant to Boost Motorcycle Safety, Awareness
    The city of Santa Clarita will present three music-related sessions at the 2018 Arts Symposium at The Centre on Saturday, Oct. 20.
    Oct. 20: Art Symposium to Stage 3 Music Sessions
    The Los Angeles County Department of Public Health reminds residents to protect themselves from flea-borne typhus by using flea control products on pets and avoiding wild or stray animals.
    Public Health Asks Residents to Help Prevent Flea-Borne Typhus
    Santa Clarita Valley Sheriff's Station deputies arrested an Antelope Valley man on multiple charges after a traffic stop in Canyon Country.
    AV Man Arrested on Multiple Charges in Canyon Country
    In this week's #FraudFriday post, the Los Angeles County Sheriff's Department warns citizens not to fall for scams when renting or leasing a home or apartment.
    Fraud Friday: Don’t Fall for Rental Scams
    Author Tina Hogan Grant will celebrate the Oct. 4 publication of her debut novel, "Reckless Beginnings," with a personal appearance and book-signing session at the Frazier Park Library on Saturday, Oct. 13 starting at 3 p.m.
    Oct. 13: ‘Reckless Beginnings’ Book Signing at Frazier Park Library
    The next meeting of Santa Clarita Valley Water's Public Outreach and Legislative Committee is scheduled for Thursday, Oct. 18, starting at 5:30 p.m.
    Oct. 18: SCV Water Public Outreach, Legislative Committee Meeting
    The Santa Clarita Valley Sheriff's Station has released its crime information and public safety report for Saugus (Zone 4) for the week of Oct. 1-7, 2018.
    Crime Blotter: GTA, Burglary in Saugus
    1915 - Name of Surrey post office & town changed (back) to Saugus [story]
    The Los Angeles County Department of Public Works and Sanitation Districts of Los Angeles County, will hold a free, household hazard and e-waste recycling roundup, Saturday, Oct. 13, from 9:00 a.m. - 3:00 p.m., for Val Verde area residents.
    Oct. 13: Household Hazardous, E-Waste Recycling Roundup in Val Verde
    The city of Santa Clarita is proud to announce that Santa Clarita singer-songwriter Karli Webster is scheduled to sing the national anthem prior to the start of the Santa Clarita Marathon, presented by Parkway Motorcars.
    Karli Webster, Former ‘Voice’ Contestant, to Sing National Anthem at SC Marathon