[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

SCVNews.com | UCLA Research Revives Hope for Lymphoma Treatment | 10-16-2012
Inside
Weather
Santa Clarita CA
Cloudy
Cloudy
63°F
 
Calendar
Today in
S.C.V. History
August 24
1974 - Pyramid Lake opens to the public [story]


[UCLA] – Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered the mechanism by which an experimental drug known as GCS-100 removes from lymphoma cells a protein that prevents the cells from responding to chemotherapy.

The discovery revives hope in a drug that had been tested in clinical trials years before but had been delayed indefinitely. The researchers hope GCS-100 can be combined with chemotherapy to create an effective treatment for diffuse large B-cell lymphoma (DLBCL), the most common and aggressive form of non-Hodgkin lymphoma, a cancer of the immune system.

The findings are published in the advance online issue of the journal Blood and will appear in a forthcoming print issue of the journal.

The UCLA researchers found that a protein called galectin-3 binds to an enzyme called CD45 on the surface of lymphoma cells. This protein–enzyme combination regulates the cancer cells’ susceptibility to chemotherapy, essentially protecting them from chemotherapy drugs.

Derived from citrus pectin, GCS-100 works outside the cancer cells to remove the protective galectin-3. Once the galectin-3 is removed, a lymphoma cell can be effectively killed by chemotherapy drugs, part of a chain reaction of programmed cancer-cell death known as apoptosis.

Although the researchers knew the drug had shown action against lymphoma cells, the finding that GCS-100 literally removed the barrier to the initiation of cell death by removing galectin-3 from the cell surface was unexpected.

“We let the results guide our ideas, and we were able to establish a mechanism for GCS-100,” said the study’s first author, Mary Clark, a graduate student researcher in pathology and laboratory medicine. “I am excited to follow the progress of GCS-100 and hope to see its use in the clinic as an adjunct therapy for lymphoma in the near future.”

Dr. Linda Baum, a professor of pathology and laboratory medicine and senior researcher on the study, said, “This drug had been abandoned because of the vagaries of the economy. My hope would be to restart this drug in clinical trials and, using this new knowledge, to include it in a more targeted lymphoma therapy.”

Early clinical trials of GCS-100 had shown no known side effects of the drug other than a mild rash in some patients, which other research has demonstrated is the result of the drug also promoting the development of T cells, which are created by the immune system to fight disease.

Funding for the research was provided by the Ron and Maddie Katz Family Foundation and the National Institutes of Health.

UCLA’s Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation’s largest comprehensive cancer centers, the Jonsson Center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2012, the Jonsson Cancer Center was once again named among the nation’s top 10 cancer centers by U.S. News & World Report, a ranking it has held for 12 of the last 13 years.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

0 Comments

You can be the first one to leave a comment.

Leave a Comment


HIGHER EDUCATION LINKS
Related Content
LOCAL COLLEGE HEADLINES
Wednesday, Aug 23, 2017
Starting Tuesday, Aug. 29, College of the Canyons students can leave their brown-bag lunches at home on Tuesdays because COC's Institute for Culinary Education (aka iCuE) Café will resume its weekly lunch service.
Wednesday, Aug 23, 2017
College of the Canyons has launched the Resources for Individual Success in Education program, dubbed RISE, to help improve access to higher education for current and former foster or homeless youth.
Tuesday, Aug 22, 2017
The CSUN Art Galleries are pleased to present part two of an exhibition featuring artwork made by full and part-time faculty in the Department of Art. More than thirty artists showcase current bodies of work, using a variety of materials and processes.
Tuesday, Aug 15, 2017
College of the Canyons is hosting 2017 Professional Development Week — a week of seminars, lectures, and workshops concerning student development and teaching.
Tuesday, Aug 15, 2017
In the fall, College of the Canyons will offer several Associate Degrees for Transfer (AD-T) at the Canyon Country campus, including Business Administration, Psychology, and Sociology.

Latest Additions to SCVNews.com
I started by asking my grandchildren what color they would use to draw a fox. I handed them a box of crayons. The situation became impossible when both started fighting over the red crayon.
The Cunning One | Commentary by Evelyne Vandersande
1974 - Pyramid Lake opens to the public [story]
Today on NewsBreak, a COC student has been arrested and charged with rape. The SCV Sheriff’s Station’s Crime Impact Team and Special Assignment Team conducted a joint bicycle patrol in Canyon Country and Newhall Tuesday evening.
SCV NewsBreak for Wednesday, August 23, 2017
Efforts to illuminate “dark money” in politics took a step forward Wednesday, as California lawmakers brokered a deal to move a disclosure bill to the state Senate next week.
‘Dark Money’ Bill Moves to California Senate
The school year is about to commence at California State University, Northridge. Saturday classes will start on Aug. 26. and weekday classes will begin on Aug. 28.
CSUN Fall 2017 Classes Start Saturday
Zonta Club of SCV's September 'LifeForward' workshop for women, focusing on how to better deal with conflict and anger issues, is set for the Savia Community Center in Newhall on Saturday, September 16 from 10 a.m. to 12:30 p.m.
September 16: Zonta Conflict, Anger Workshop
Six Flags Entertainment today announced its Southern California flagship property, Six Flags Magic Mountain, will be open 365 days a year starting January 1, 2018.
Six Flags Magic Mountain Goes Year-Round in January
The Ekata Training Center in Valencia will host a Fitness Fun Day and open house on Saturday, September 16 from 5 p.m. to 8 p.m.
September 16: Ekata Training Center Fitness Fun Day
Air quality will be unhealthy for sensitive individuals in the Santa Clarita Valley on Thursday, the AQMD warns.
Bad Air Rising in SCV Thursday
A five-week project to install a reinforced concrete box storm drain under Railroad Avenue in Newhall to improve drainage in the area will start Monday, August 28.
Railroad Ave. Storm Drain Project Begins August 28
Nine cancer survivors and their physicians will take the field at Dodger Stadium on Saturday evening to kick off City of Hope’s ThinkCure! Weekend.
Dodger Fans Help Strike Out Cancer This ‘Think Cure’ Weekend
Deputy Natalie Hidalgo is the Santa Clarita Valley Sheriff Station's newly appointed school resource officer for Golden Valley High School, Sierra Vista Junior High School and Sequoia School.
Natalie Hidalgo New School Resource Deputy in Canyon Country
Starting Tuesday, Aug. 29, College of the Canyons students can leave their brown-bag lunches at home on Tuesdays because COC's Institute for Culinary Education (aka iCuE) Café will resume its weekly lunch service.
August 29: COC’s ‘iCuE’ Lunch Service Resumes
College of the Canyons has launched the Resources for Individual Success in Education program, dubbed RISE, to help improve access to higher education for current and former foster or homeless youth.
COC Launches RISE Program to Aid Foster, Homeless Youth
International contemporary art gallery Hauser & Wirth launched an exchange program for post-MFA students from CalArts and the Bath School of Art and Design, Bath Spa University in the UK.
Hauser & Wirth’s Artist Residency Exchange at CalArts and Bath School
Artists and CalArts alumni Kenyatta A. C. Hinkle (Art, Critical Studies MFA 12) and Scott Benzel (Art MFA 01) will take part in The Getty’s 'Friday Flights' on Friday, August 25 from 6 p.m. to 9 p.m.
August 25: CalArtians to Perform at The Getty’s ‘Friday Flights’
Another COC student has been arrested and charged with rape in an accusation unrelated to an on-campus assault reported Monday, this time for an alleged sexual assault that took place off-campus in June.
Another COC Student Charged in Alleged Sexual Assault
California's Assembly Appropriations Committee plans to review the Santa Clarita Valley Water District bill, SB 634, on September 1, Assembly officials said Wednesday.
Assembly Committee to Review SCV Water District Legislation
The city of Los Angeles filed a lawsuit Tuesday to intervene in California and San Francisco’s actions against the Justice Department’s new conditions on sanctuary cities.
L.A. Joins Sanctuary Cities’ Fight Against Justice Department
The SCV Sheriff's Station's Crime Impact Team and Special Assignment Team conducted a joint bicycle patrol in Canyon Country and Newhall Tuesday evening, and arrested four people on drug charges.
SCV Deputies’ Bicycle Patrol Nets 4 Arrests for Drugs
The 21st annual "Heart of the West" fundraiser for the non-profit Carousel Ranch horse therapy program for children will take place at the ranch on Saturday, August 26 starting at 6 p.m.
August 26: ‘Heart of the West’ to Benefit Carousel Ranch
Beatles tribute band The Sun Kings headline the final show in the 2017 Concerts in the Park series on Saturday, August 26, starting at 7 p.m.
August 26: Sun Kings Beatles Tribute Band at Central Park
Garrett Hampson delivered four hits and the Lancaster JetHawks held off a late rally by the Inland Empire 66ers in a 9-8 victory on Tuesday night at The Hangar, the JetHawks' fifth win in a row.
Hampson’s 4 Hits Propel JetHawks Over 66ers
The California League has named three Lancaster JetHawks as Postseason All-Stars -- Garrett Hampson, Yonathan Daza and Wes Rogers.
Three JetHawks Earn Post-Season All-Star Nods
The Santa Clarita City Council recognized the Santa Clarita Valley Sheriff Station's two Employees of the Month, Deputy Bob Garcia and Custody Assistant Manny Ramirez, at the Council's meeting Tuesday night.
City Council Honors SCV Sheriff’s Station Employees of the Month
1963 - First stretch of Antelope Valley 14 Freeway opens from east of Solemint Junction in Canyon Country to Red Rover Mine Road in Acton. [story]
With funding from Measure H, Los Angeles County and its cities are teaming up to quickly place thousands of homeless people into permanent housing that comes with the supportive services, rental subsidies and other assistance needed to thrive.
Permanent, Supportive Housing for Homeless Thanks to Measure H
A Domestic Violence Center, Senior Center and homeless shelter partnership is looking for solutions to the countywide homelessness crisis in Santa Clarita.
Three Local Non-Profits Look to Tackle Housing Crisis
The Gibbons Conservation Center is holding a Back to School special. Buy your 2018 membership today and get the rest of 2017 free.
Gibbons Conservation Center Holding Back-to-School Special
Tonight on SCV NewsBreak, CHP is investigating a fatal collision that happened early Tuesday morning near Castaic. Plus, photographers can get ready to submit their Santa Clarita-centric photos for the Fall 2017 Photo Contest. Watch these stories and more on tonight's edition of SCV NewsBreak.
SCV NewsBreak for Tuesday, August 22, 2017
WiSH Foundation Executive Director Amy Daniels is about climb for education.
WiSH Foundation’s E.D. to Climb Kilimanjaro for Public Education
Registration for the Fall session is now open.
Lil’ Kickers Fall Registration Underway
The CSUN Art Galleries are pleased to present part two of an exhibition featuring artwork made by full and part-time faculty in the Department of Art. More than thirty artists showcase current bodies of work, using a variety of materials and processes.
CSUN Faculty Artwork on Display in “Full and Part (Two)” Exhibit
Here are the upcoming times and dates for the Santa Clarita Valley Chamber of Commerce Emerging Leaders Series:
Chamber’s Emerging Leaders Series Resumes Wednesday
Mayor Cameron Smyth, Mayor Pro Tem Laurene Weste and Councilmembers Bill Miranda, Marsha McLean and Bob Kellar cordially invite you to party like it’s 1987 at the 2017 State of the City Luncheon to be held on Thursday, October 26, 2017 at 11:30 a.m. at the Hyatt Regency Valencia.
Oct. 26: State of the City 30th Anniversary Luncheon
Join The Painted Turtle on October 14, 2017 for the 8th annual bike ride and 2nd annual walk/run/roll to benefit the non-profit.
Oct. 14: Tour de Turtle, Turtle Trek Bike Ride