[Sign Up Now] to Receive Our FREE Daily SCVTV-SCVNews Digest by E-Mail

SCVNews.com | SCV Biotech Reports Success in Arthritis Treatment Study | 11-12-2012
Inside
Weather
Santa Clarita CA
Cloudy
Cloudy
65°F
 
Calendar
Today in
S.C.V. History
August 21
1961 - CalArts grad (MFA '92) and marine biologist Stephen Hillenburg, creator of Spongebob SquarePants, born in Oklahoma; developed prototype for Spongebob while studying at CalArts in 1989. Estimated net worth in 2012: $90 million [story]


[SetPoint] – SetPoint Medical, a Valencia-based biomedical technology company developing neuromodulation therapies for inflammatory diseases, presented positive results from a first-in-human study using a neuromodulation device to treat rheumatoid arthritis (RA) Sunday at the American College of Rheumatology annual meeting in Washington, D.C.

“In contrast to immunosuppressive drugs, the neuromodulation therapy in this study used an implantable pulse generator to stimulate the vagus nerve, activating the body’s natural Inflammatory Reflex to produce a systemic anti-inflammatory effect,” said Dr. Kevin Tracey, President of Feinstein Institute for Medical Research, discoverer of the inflammatory reflex, and co-author of the ACR presentation. “The results of this study show promising clinical efficacy, and confirm a decade of foundational scientific research done by our laboratory and others.”

“This study validates neuromodulation as a breakthrough approach to treating RA and other autoimmune and inflammatory diseases,” said Anthony Arnold, chief executive officer of SetPoint Medical. “We look forward to developing safe and effective alternative therapies for a range of inflammatory diseases such as Crohn’s disease, ulcerative colitis, psoriasis, and for the inflammation that worsens diabetes and heart disease. This approach could offer patients 10 years of treatment for the cost of about 18 months of biologic therapy and would be an exciting new alternative for physicians to treat their patients.”

In this open label pilot study, eight patients with active rheumatoid arthritis despite treatment with the RA agent methotrexate, who would otherwise have been candidates for a TNF inhibitor, instead received the neuromodulation implant on the vagus nerve in their neck. The treatment was well tolerated, with one patient reporting hoarseness after implantation, a known side effect with this type of device. Improvement in RA was assessed at the six-week primary endpoint using standard measures of efficacy including the Disease Activity Score (DAS), and the American College of Rheumatology (ACR) 20 response rate.

At the primary end point, two of the eight patients in the study achieved DAS remission, and six of the eight had a positive ACR 20 response, results similar to those typically achieved in larger studies with drugs currently used to treat RA.

SetPoint is developing a novel platform to treat a variety of inflammation-mediated autoimmune diseases. The company is planning larger clinical studies in several diseases scheduled to begin in 2013.

 

About SetPoint Medical

SetPoint Medical is a privately held biomedical technology company dedicated to treating patients with debilitating inflammatory diseases using proprietary implantable neuromodulation devices.

SetPoint is developing safe and effective neuromodulation therapies for patients with inflammatory autoimmune diseases, such as Crohn’s Disease and rheumatoid arthritis. SetPoint’s novel platform consists of an implantable miniature neuromodulation device, wireless charger and iPad prescription pad application. The system uses vagus nerve stimulation to activate the body’s natural Inflammatory Reflex, which produces a potent systemic anti-inflammatory effect. The company has just completed a first-in-human open-label proof-of-concept trial in rheumatoid arthritis. The results confirm extensive preclinical studies, and show clinical efficacy comparable to leading immunosuppressive drugs. SetPoint’s approach is intended to offer patients and providers a better alternative approach for the treatment of RA and other chronic inflammatory diseases with less risk and cost than drug therapy. SetPoint is headquartered in Valencia, Ca., and investors in the company include Morgenthaler Ventures, Foundation Medicine and Topspin Partners. For more information, visit www.setpointmedical.com.

Comment On This Story
COMMENT POLICY: We welcome comments from individuals and businesses. All comments are moderated. Comments are subject to rejection if they are vulgar, combative, or in poor taste.
REAL NAMES ONLY: All posters must use their real individual or business name. This applies equally to Twitter account holders who use a nickname.

No Comments

    Leave a Comment


    LOCAL BUSINESS LINKS
    LOCAL BUSINESS HEADLINES
    FINANCIALS OF LOCAL INTEREST
    MARKETS & METALS
    NASDAQ6205.2285  chart -0.18%
    S&P 5002421.51  chart -0.17%
    STOCKS OF LOCAL INTEREST
    Bank Santa Clarita18.00  chart +0.00%
    Biosolar Inc Com Usd0.0001(post0.041  chart +0.00%
    Sierra Bancorp25.06  chart -1.30%
    Cu Bancorp (ca)34.95  chart -0.29%
    Enable Ipc Corp. Com Stk Npv0.001  chart +0.00%
    Flex Ltd. - Ordinary Shares15.575  chart +0.35%
    N/aN/A  chartN/A
    N/aN/A  chartN/A
    Mannkind Corporation1.415  chart -3.08%
    Mission Vly Bcp Ca13.81  chart +0.00%
    Quest Diagnostics Incorporated105.0965  chart +0.22%
    Tejon Ranch Co19.96  chart -0.30%
    Us Energy Initiative0.0004  chart -20.00%
    Wesco Aircraft Holdings, Inc.7.775  chart +0.32%

    Apple Inc.157.70  chart +0.13%
    At&t Inc.37.4605  chart +0.24%
    Autonation, Inc.42.15  chart +1.13%
    Best Buy Co., Inc.59.85  chart +0.64%
    Big Lots, Inc.49.28  chart -0.34%
    Barnes & Noble, Inc.7.30  chart -0.68%
    Brady Corporation32.60  chart -0.31%
    Boston Scientific Corporation26.865  chart -0.09%
    N/a24  chart +0.00%
    Cbre Group Inc Class A35.49  chart +0.71%
    Carnival Corporation67.80  chart +0.50%
    Comcast Corporation40.70  chart +0.44%
    Costco Wholesale Corporation156.61  chart -0.30%
    Curtiss-wright Corporation93.884  chart +0.34%
    Cvs Health Corporation77.74  chart +0.10%
    Cemex, S.a.b. De C.v. Sponsored9.22  chart +0.22%
    D.r. Horton, Inc.35.67  chart -0.06%
    Walt Disney Company (the)100.77  chart +0.07%
    Edison International78.98  chart +0.05%
    Hyatt Hotels Corporation Class 56.14  chart +0.23%
    Home Depot, Inc. (the)147.655  chart +0.11%
    Kb Home22.255  chart +0.20%
    Kroger Company (the)22.88  chart +0.09%
    Lennar Corporation Class A51.95  chart +0.13%
    Laboratory Corporation Of Ameri154.37  chart +0.30%
    N/aN/A  chartN/A
    N/aN/A  chartN/A
    Lowe's Companies, Inc.73.66  chart +0.03%
    Marriott International98.13  chart +0.10%
    Mcdonald's Corporation158.17  chart +0.26%
    Mitsubishi Ufj Financial Group,6.12  chart -1.77%
    Netflix, Inc.168.18  chart +0.98%
    Office Depot, Inc.4.15  chart +0.73%
    Rite Aid Corporation2.22  chart +0.00%
    Rexford Industrial Realty, Inc.28.34  chart -0.07%
    Regal Entertainment Group Class14.90  chart -1.46%
    Ross Stores, Inc.58.4568  chart -0.95%
    Republic Services, Inc.64.03  chart +0.22%
    N/aN/A  chartN/A
    Starbucks Corporation52.89  chart +0.36%
    Smart & Final Stores, Inc.7.425  chart -1.66%
    Sears Holdings Corporation8.515  chart -1.56%
    Six Flags Entertainment Corpora52.99  chart -1.67%
    Sonova N159.70  chart -0.44%
    Staples, Inc.10.20  chart +0.10%
    Sunpower Corporation9.11  chart -1.41%
    Target Corporation55.82  chart +0.31%
    Time Warner Cable Inc209.56  chart -0.21%
    Ulta Beauty, Inc.238.0768  chart -2.51%
    Walgreens Boots Alliance, Inc.80.45  chart +0.52%
    Waste Connections, Inc.63.6223  chart +0.00%
    Whole Foods Market, Inc.41.74  chart +0.02%
    Waste Management, Inc.75.48  chart +0.31%
    Wal-mart Stores, Inc.79.17  chart -0.18%
    Woodward, Inc.67.91  chart +0.07%
    CURRENCY CONVERTER

    Latest Additions to SCVNews.com
    1961 - CalArts grad (MFA '92) and marine biologist Stephen Hillenburg, creator of Spongebob SquarePants, born in Oklahoma; developed prototype for Spongebob while studying at CalArts in 1989. Estimated net worth in 2012: $90 million [story]
    The Santa Clarita Public Library invites residents to view the total solar eclipse on Monday, August 21 at the Old Town Newhall Library starting at 10 a.m.
    August 21: Solar Eclipse Viewing at Newhall Library
    1967 - New Town of Valencia dedicated; homes sell for $25,000 [story]
    1879 - Newhall civic leader Charles Henry Kingsburry born in Missouri [story]
    Alerted by a concerned citizen Friday, Santa Clarita Valley Sheriff's Station deputies once again rescued dogs the owner left in a car with the windows rolled up and no water.
    Deputies Break Window, Rescue Dogs Locked in Car
    40 oz. to Freedom arrives in Santa Clarita as part of its anniversary tour at Concerts in the Park at Central Park on Saturday, August 19, with showtime at 7 p.m.
    August 19: 40 Oz. to Freedom Rocks Central Park
    Two local environmental groups filed a complaint in L.A. Superior Court Thursday regarding the approved plan to provide water to the Newhall Ranch development, set to break ground in 2018.
    Environmental Groups File Complaint Against Newhall Ranch Water Plan
    County Supervisor Kathryn Barger has provided $143,000 in funding to extend the season of youth and adult swim programs offered at the Castaic Aquatic Center through October 31.
    Castaic Aquatic Center Programs Extended to October 31
    Tonight on SCV NewsBreak, Los Angeles County firefighters and government leaders welcomed back the Super Scoopers Friday morning. Plus, the Old Town Newhall Library helped get the community ready for it as well by handing out free eclipse viewing glasses. Watch these stories and more on tonight's edition of SCV NewsBreak.
    SCV NewsBreak for Friday, August 18, 2017
    CalArts alumna Audrey Chan (Art MFA 07) will host a free, all-ages interactive arts workshop in Little Tokyo on Saturday and Sunday, August 19 and 20, as part of the Japanese American Cultural & Community Center’s 2017 Nisei Week activities.
    August 19-20: Nisei Week Arts Workshop with CalArts Alum Audrey Chan
    Western singer and songwriter John Zipperer headlines the next episode of "SCVTV Presents The OutWest Concert Series" at The MAIN in Old Town Newhall the evening of Friday, August 25.
    August 25: John Zipperer Headlines ‘SCVTV Presents The OutWest Concert Series’
    Habitat for Humanity SFV/SCV is honored to have received a $25,000 grant from the Disabled Veterans National Foundation, which will fund trauma workshops.
    Habitat for Humanity Receives $25K Grant from Disabled Veterans
    Here are agenda highlights for the next meeting of the Los Angeles County Board of Supervisors, set for Tuesday, August 22, starting at 9:30 a.m..
    August 22: Board of Supervisors Meeting Agenda
    Ashley Olivier, a student worker at the Santa Clarita Valley Sheriff's Station, summited Mt. Whitney with her dad, a lieutenant at LASD's Monterey Park station.
    SCV Sheriff’s Station Student Worker, LASD Dad Top Mt. Whitney
    Looking to enter the win column for the first time in 2017 on day two of the Summer Slam volleyball tournament, the TMU Mustangs squared off against 11th-ranked Eastern Oregon but lost in straight sets.
    Mountaineers Spike Mustangs at Summer Slam
    Caltrans has released "Rail and the California Economy," a research report investigating how the state’s vast passenger and freight rail system contribute to California’s economy, as well as an overview of opportunities for rail to address the state’s needs and challenges in the future.
    New Report Details Rail Role in State Economy
    The Master’s University women’s soccer team soared to a 7-0 victory over the visiting Eagles from Sierra Nevada College Thursday.
    Lady Mustangs Soccer Win Opener 7-0
    The Master’s University women's volleyball team concluded their first day of HIU Summer Slam tournament play with a five-set thriller against the Southern Oregon University Raiders on Wednesday evening, dropping the fifth set 15-9.
    Lady Mustangs Fall in 5 to Raiders at HIU
    A federal judge on Wednesday ruled against claims by a state workers’ union that California’s pension system unfairly changed the terms of a pre-existing collective bargaining agreement.
    Court Upholds Increase in CalPERS Retirement Age
    Friday's alert from the South Coast Air Quality Management District that air quality will be unhealthy for sensitive individuals in the Santa Clarita Valley has been extended through Saturday.
    Updated: SCV Air Quality Unhealthy Saturday
    Four annual crime reports, which provide law enforcement agencies and the public with statewide data on crime statistics, were released Friday by California's Attorney General.
    AG Releases 4 California Crime Reports for 2016
    The Master’s University women’s volleyball team lost their 2017 season opener Wednesday at the HIU Summer Slam in straight sets against the Warriors from national powerhouse Corban University (OR).
    Warriors Drop TMU Lady Mustangs in Straight Sets
    Here's the Castaic/Val Verde (Zone 2) Crime Information and Public Safety Report from the Santa Clarita Valley Sheriff's Station for the week of August 7 to August 13.
    Crime Blotter: Assault, Theft in Castaic-Val Verde
    Two Santa Clarita Valley Sheriff's Station employees will be recognized at the City Council meeting to be held on August 22 at 6 p.m.
    City Council to Honor 2 SCV Sheriff’s Station Employees
    The city of Santa Clarita’s Youth Sports program has seen measured success thus far in 2017.
    Santa Clarita Youth Sports Program Sees Spike in Participation
    The Santa Clarita Valley Senior Center’s new building campaign now only has $1.3 million remaining to raise before groundbreaking on the site can begin.
    New SCV Senior Center Needs $1.3M to Break Ground
    Sacramento County sued the California Department of Water Resources on Thursday over DWR's certification of the California 'WaterFix' delta tunnels project’s “dizzying” and “shifting” environmental review.
    Sacramento County Sues to Freeze California ‘WaterFix’
    1946 - Pioneering Placerita Canyon movie producer Trem Carr dies in San Diego [story]
    ' style=
    The storewide remodel of the Walmart Supercenter at 26471 Carl Boyer Drive is complete and, in addition to the many physical changes inside, Santa Clarita residents now have access to Online Grocery Pickup.
    Walmart on Carl Boyer Drive Celebrates Grand Reopening Friday
    Tonight on SCV NewsBreak, two people have been hospitalized after a major collision. Plus, an acquisition of land near the 14. Watch these stories and more on tonight's edition of SCV NewsBreak.
    SCV NewsBreak for Thursday August 17, 2017
    Le Chene French Cuisine, a long-time Santa Clarita local favorite restaurant along Sierra Highway, has announced that they will be hosting a thrilling Murder Mystery Dinner on Saturday, November 4th, 2017.
    Nov. 4: Le Chene Murder Mystery Dinner
    Senator Scott Wilk, R- Antelope Valley, today announces that he is one of the 2017 inductees into the Antelope Valley High School Alumni Hall of Fame.
    Sept. 22: Wilk to be Inducted into AV High School Hall of Fame
    Signups are under way for the Santa Clarita Walk to End Alzheimer’s, which offers participants an opportunity to take a healthy stroll, experience outstanding live entertainment, honor loved ones who have been affected by Alzheimer’s and raise funds to battle the debilitating disease.
    Oct. 7: Walk to End Alzheimer’s; Signups Under Way
    Trammell Crow Company (TCC) andand Clarion Partners are pleased to announce the acquisition of 54 acres of land for the development of The Center at Needham Ranch, a state-of-the-art business park in the city of Santa Clarita, CA.
    TCC, Clarion Partners Acquire More Than 50 Acres of SCV Real Estate